Inflammatory markers in men with metabolic syndrome genotyped to -455G/A polymorphism in beta-fibrinogen gene
Journal Title: Postępy Nauk Medycznych - Year 2011, Vol 24, Issue 9
Abstract
Low-grade inflammation is a characteristic feature of metabolic syndrome and significantly contributes to cardiovascular risk in affected subjects. The level of inflammatory process development is influenced by different metabolic and genetic factors. In the present study the association between -455G/A genetic variants in fibrinogen gene and plasma levels of CRP and adhesion molecules was assessed in 61 men with newly diagnosed metabolic syndrome. DNA was amplified by polymerase chain reaction and incubated with the restriction enzyme. Circulating levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were measured by enzyme-linked immunosorbent assay (ELISA). Serum high-sensitivity CRP was determined by immunoturbidimetric method. The -455G/A genotype frequencies were 60%, 22%, and 7% for GG, GA, and AA, respectively. It was found that fibrinogen, CRP and adhesion molecules concentrations were enhanced in A-allele carriers as compared to GG homozygotes, and these differences were not related to BMI, and serum lipids and glucose levels.
Authors and Affiliations
Marta Włodarczyk, Agnieszka Jarosz, Grażyna Nowicka
Keywords
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