Inflammatory Myofibroblastic Tumour –An Unusual Tumour with Intermediate Malignant Potential- Report of Three Cases
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 12
Abstract
Inflammatory Myofibroblastic Tumour (IMT) is a rare mesenchymal neoplasm of borderline malignancy. It is characterised by proliferation of myofibroblasts and fibroblasts with variable amount of inflammatory infiltrate. About 50-60% of the cases show Anaplastic Lymphoma Kinase (ALK) rearrangements. The recurrence rate and metastasis depends on the anatomic site, resectability, size and presence of ALK rearrangements. In this case series, we are presenting three cases diagnosed as IMT. All the patients were elderly. Sites included abdomen, subcutaneous tissue over scapula and orbit. Scapular lesion presented as recurrence in six months after first excision. All three cases were ALK negative. IMTs that occur in elderly persons can mimic malignancy. Surgical excision is the treatment of choice. Diagnosis depends on histopathological features and immunohistochemical examination. Correct histological diagnosis is crucial for further management. Chance of recurrence and metastasis is more in abdominopelvic location, large size and ALK negativity. This case series aims to create awareness of the non-specific presentation of this tumour and need of follow up as this tumour may recur in a very short interval.
Authors and Affiliations
Dr. Indusarath, Sangeetha K Nayanar, Nizamudheen M Pareekutty, B Satheesan, Satheesh Babu
Keywords
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- EP ID EP367584
- DOI 10.7860/JCDR/2017/32212.11008
- Views 43
- Downloads 0
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