Inflammatory Response and Pathophysiology of IL-6 Overproduction: A Review Article
Journal Title: International Journal of Health & Medical Research - Year 2024, Vol 3, Issue 08
Abstract
Interleukin-6 (IL-6) has been considered a multifunctional interleukin, belongs to the pro-inflammatory cytokines, stimulate the production of various polypeptides accounted for acute inflammatory response, and exerts a crucial function in the cells’ division, survival and differentiation of and is responsible for many cellular metabolic alterations. Interleukin (IL)-6 is formed at the location of inflammatory response and perform a principal function in the acute inflammatory phase stage by the release of many acute phase polypeptides. Overproduction of IL-6 has been found to be a major cause in the pathophysiology of several illnesses including post-menopausal osteoporosis, psoriasis, Castleman’s disease, rheumatoid arthritis, inflammatory bowel disease, pyelonephritis and multiple myeloma. Studies suggested that IL-6 can be recommended as a key indicator for prediction of elongated COVID-19 status and to determine “early stage” of extended COVID-19. This review aims to state the main mechanisms by which Il-6 exert its role during inflammatory response and its pathophysiological aspects in the development of many diseases
Authors and Affiliations
Rabab Shaker Salman, Bushra A. M. Abdul Azeez, Maha Chasib Munshid, Ali A. Al-fahham,
Keywords
Related Articles
- EP ID EP750574
- DOI 10.58806/ijhmr.2024.v3i08n05
- Views 26
- Downloads 0
Etiology, Epidemiology and Pathophysiology of Vaginitis
Vaginitis is a common condition that affects women; it is an inflammation of the vagina, an infection that creates abnormal discharge followed by irritations and itching. Being aware of the etiology and epidemiology of v...
Etoricoxib-Induced Linear IgA Bullous Dermatosis
Linear IgA bullous dermatosis is a rare subepidermal bullous disease that can occur idiopathically or to be druginduced. The disease affects both the skin and mucous membranes in children and adults. Drug-induced linear...
The Histopathology and Treatment Strategies of Adenocarcinoma
Adenocarcinoma is a cancer of glandular tissue and, therefore, poses considerable problems for diagnosis and treatment. The diverse nature of this cancer mandates a proper staging system for the guidance of treatment app...
A Review of Perspectives from Earth Observation Data to Investigate the Effects of COVID-19 on The Environment
Background: Earth observation data has established themselves as extremely useful and very diverse domains for research associated with space, spatio-temporal components, and geography. Following the outbreak of Severe...
Correlation of Structural Uterine Abnormalities with Abnormal Uterine Bleeding Among Premenopausal Women with Infertility
Objective: To document the various structural uterine abnormalities detected on transabdominal ultrasonography (TAUS) and hysterosalpingography (HSG) of premenopausal women with infertility and abnormal uterine bleeding...