Influence of aqueous medium (heavy metal salts) on non-specific mechanisms of regulation of hemopoiesis under conditions of subacute action and antioxidant correction (a-tocopherol)
Journal Title: Екологічні науки - Year 2018, Vol 20, Issue 1
Abstract
An examination of the blood composition may indicate the transition from the physiological state of the organism to the pathological, including through action on it exogenous factors (salts of heavy metals). To date, there are known mechanisms for regulation of hematopoiesis, including the neuroendocrine system. Experiment was simulated in 36 white male rats at the age of 5–6 months. The experimental group of animals used for 30 days the usual drinking water, saturated with a combination of heavy metal salts, which is characteristic of reservoirs in the northern regions of the Sumy region. Animals of the experimental group II for 30 days, together with the use of a combination of heavy metal salts, received vitamin E (α-tocopherol acetate). The hematological parameters and functional state of the pituitary gland, adrenal cortex and testes (ACTH (pg/ml), cortisol COR (nmol/l), DHS (umol/l) and TEES (pg/ml)) were studied. The salts of heavy metals negatively affect the functional state of the endocrine mechanisms of regulation of hemopoiesis, causing the development in the body of the stage of exhaustion of the general adaptive syndrome. L-tocopherol reduces the severity of the cytotoxic action of heavy metals on blood cells, helps to reduce the toxic effects of heavy metal salts on the adrenal cortex, weakens manifestations of the stage of exhaustion of the general adaptive syndrome and restores hormonal balance in the pituitary-adrenal and reproductive panel of the androgenic part of the endocrine system of the rats.
Authors and Affiliations
Н. Б. Гринцова, А. М. Романюк, М. С. Линдін, Ю. М. Линдіна
Keywords
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