Influence of aripiprazole on the antidepressant, anxiolytic and cognitive functions of rats.
Journal Title: Pharmacological Reports - Year 2011, Vol 63, Issue 4
Abstract
Recent research has suggested that cognitive disorders are a persistent trait of mental illnesses such as schizophrenia. Cognitive deficits in the course of schizophrenia may be due to the disease and/or drug therapy, especially with old-generation drugs. Several clinical experiments have indicated the beneficial effects of new-generation antipsychotics on cognitive processes in patients treated for mental disorders. Aripiprazole is a new, atypical antipsychotic with a unique mechanism of action, which may have positive effects on cognitive functions. The aim of this study was to investigate the effects of aripiprazole on spatial memory in the Morris water maze and antidepressant activity in the Porsolt test. In addition, we examined whether aripiprazole had any side effects in the chimney test. The behavioral tests showed that aripiprazole improved spatial memory in rats and had antidepressant and anxiolytic effects after a single treatment; however, aripiprazole impaired motor coordination after repeated administration. We concluded that aripiprazole could be an effective antipsychotic for the treatment of patients with schizophrenia or bipolar disorder who have associated anxiety and cognitive deficits.
Authors and Affiliations
Kinga Burda, Anna Czubak, Krzysztof Kus, Elżbieta Nowakowska, Piotr Ratajczak, Jennifer Zin
Keywords
Related Articles
- EP ID EP155601
- DOI -
- Views 87
- Downloads 0
Up-regulation of vascular cyclooxygenase-2 in diabetes mellitus.
Diabetes mellitus is associated with disturbed regulation in the microcirculation. A low-grade vascular inflammation has been implicated in the development of diabetes-related vascular complications, but the underlying m...
Effects of co-treatment with mirtazapine and low doses of risperidone on immobility time in the forced swimming test in mice.
The aim of the present study was to examine the effect of mirtazapine (MIR) and risperidone (an atypical antipsychotic drug), given separately or jointly, on immobility time in the forced swimming test in male C57BL/6J m...
Effect of resveratrol on scopolamine-induced cognitive impairment in mice.
Background: Resveratrol (3,4',5-trihydroxystilbene) is a naturally occurring compound found in grapes, wine, peanuts and cranberries. Recently, in vitro and cell culture studies have reported beneficial effects of resver...
Effects of the noradrenergic neurotoxin DSP-4 on the expression of α(1)-adrenoceptor subtypes after antidepressant treatment.
We have previously reported that chronic imipramine and electroconvulsive treatments increase the α(1A)-adrenoceptor (but not the α(1B) subtype) mRNA level and the receptor density in the rat cerebral cortex. Furthermore...
Preserved coronary arteriolar dilatation in patients with type 2 diabetes mellitus: Implications for reactive oxygen species.
Type 2 diabetes mellitus is associated with clustering of cardiovascular risk factors that may greatly increase individuals' risk of developing coronary artery disease. Type 2 diabetes is believed to impair coronary func...