Influence of atorvastatin on serum amyloid A-low density lipoprotein complex in hypercholesterolemic patients.
Journal Title: Pharmacological Reports - Year 2012, Vol 64, Issue 1
Abstract
The complex of serum amyloid A(SAA) and low-density lipoprotein (LDL), SAA-LDL, is considered a new and unique marker of oxidatively-modified LDL particles, which is associated with atherosclerotic conditions. This study investigated the influence of atorvastatin treatment on circulating SAA-LDL levels among asymptomatic hypercholesterolemic patients. A total of 26 patients (mean age 63 years) received 10 mg/daily atorvastatin during a 12-week treatment period. The levels of LDL cholesterol and SAA-LDL, but not high-sensitivity C-reactive protein and SAA, were significantly reduced after the treatment. Stepwise adjusted regression analyses revealed that changes of SAA-LDL were significantly and positively correlated with those of SAA, while absolute changes were small, which warrants further investigation. The results suggest that atorvastatin may beneficially reduce SAA-LDL, and SAA-LDL may be a sensitive measure for monitoring the efficacy and antioxidant functions of atorvastatin.
Authors and Affiliations
Kazuhiko Kotani, Toshiyuki Yamada, Michiaki Miyamoto, Shun Ishibashi, Nobuyuki Taniguchi, Alejandro Gugliucci
Keywords
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