Influence of chlorpyrifos on the profile of subpopulations of immunoactive cells and their phagocytic activity in an experimental [i]in vivo[/i] model
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2012, Vol 19, Issue 3
Abstract
Many environmental factors, including pesticides, cause immunological system disorders by inducing changes in humoral and cellular response. They may stimulate or trigger immunological autoaggression, hypersensitivity and allergy, as well as lead to immunosuppression, thus increasing the incidence of infectious diseases and cancers. Such activity is also attributed to organophosphorus compounds used in agriculture as insecticides, and commonly in households as biocides. The aim of the study was to define possible mechanisms of the immunotoxic activity of the chlorpyrifos (an organophosphorus compound) on experimental animals following their exposure to the compound [i]via[/i] the oral route. The present study attempts to define the influence of chlorpyrifos on the profile of subpopulations of immunoactive cells: B, T, CD4+, CD8+, and NK, and on their phagocytic activity in an experimental [i]in vivo[/i] model. For this purpose, the Wistar rats, were exposed orally to increasing doses of chlorpyrifos: 0.1 LD[sub]50[/sub], 0.15 LD[sub]50[/sub], 0.2 LD[sub]50[/sub], 0.3 LD[sub]50[/sub] and 0.4 LD[sub]50[/sub] for 28 days. In the study animals, we failed to demonstrate a statistically significant decrease in the phagocytic activity of the granulocyte.
Authors and Affiliations
Justyna Noworyta-Głowacka, Robert Bańkowski, Joanna Siennicka, Bożena Wiadrowska, Martyna Beresińska, Jan Krzysztof Ludwicki
Keywords
Related Articles
- EP ID EP80496
- DOI -
- Views 114
- Downloads 0
Forecasting ARIMA models for atmospheric vineyard pathogens in Galicia and Northern Portugal:[i] Botrytis cinerea[/i] spores
[i]Botrytis cinerea[/i] is the cause of the most common disease in the Galician and Portuguese vineyards. Knowledge of the spore levels in the atmosphere of vineyards is a tool for forecasting models of the concentration...
Telemedical systems for home monitoring of patients with chronic conditions in rural environment
This paper describes the requirements and possible implementations of a telemedical system. The idea of remote patient monitoring is a point of interest for researchers in Poland, and is also in high demand in fields suc...
Study on the concentration of airbone respirable asbestos fibres in rural areas of the Lublin region in south-east Poland
Objective. The objective of the study was measurement of the concentrations of airborne asbestos fibres in the rural environment of the Lublin Region in south-east Poland. Methods. Measurements of concentrations of res...
Psychoactive substances use experience and addiction or risk of addiction among by Polish adolescents living in rural and urban areas
The objective of the study was to determine the similarities and differences between adolescents with psychoactive substances use experience living in urban and rural areas as regards the intensity of Internet addiction...
Evaluation of the effectiveness of neurofeedback in the reduction of Posttraumatic stress disorder (PTSD) in a patient following high-voltage electric shock with the use of ERPs
Background. The aim of our research was an evaluation of the effectiveness of neurofeedback in reducing the symptoms of Post-trauma stress disorder (PTSD), which had developed as a result of a high-voltage electric burn...