INFLUENCE OF HIGH-ENERGY DIET ON ENZYME ACTIVITY OF MAIN COMPLEXES OF MITOCHONDRIAL RESPIRATORY CHAIN AND ACTIVITY OF H+– ATPASE OF MITOCHONDRIAL INNER MEMBRANE OF RAT HEPATOCYTES
Journal Title: Праці Наукового товариства ім. Шевченка - Year 2017, Vol 49, Issue
Abstract
Previously, it has been demonstrated on rats that 20 week high-energy diet (HED) leads to non-alcoholic fatty liver disease development, which was closely correlated with visceral adiposopathy and insulin resistance. Taking into consideration a known fact that hepatocytes contain a large amount of mitochondria (each hepatocyte contains 800 mitochondria which makes approximately 18% of a hepatocyte), researchers have assumed that mitochondrial function is one of the main regulators of lipid in liver , and mitochondrial dysfunction contributes to hepatic steatosis development. It is repeatedly emphasized in literature, that changes in liver which precede steatosis development as well as attend it, are still unanalyzed. For instance, fi ndings concerning the change of enzyme activity of a respiratory chain and energy-dependent processes in hepatocytes mitochondria are inconsistent. This is the basis for formulation of the research objective.
Authors and Affiliations
M. M. Kondro, T. V. Berehova, L. I. Ostapchenko
Keywords
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