INFLUENCE OF IZONIAZIDE DERIVATIVES ON LACTAMASEPRODUCING STAPHYLOCOCCUS AUREUS SENSITIVITY TO PENICILLIN
Journal Title: Мікробіологія і біотехнологія - Year 2014, Vol 0, Issue 4
Abstract
Aim. The detection of the ability of S. aureus strains isolated from human upper airways to β-lactamase production and determination of the effect of p-dimethylaminobenzaldehyde isonicotinoylhydrazone and Sn(IV) complex with 2-hydroxyinaphtaldehyde isonicotinoylhydrazone on the sensitivity of lactamase-producing strains to penicillin. Methods. We have used the microbiological methods: disc-diffusion, double-disc and serial dilution methods and statistical data analysis. Results. 33 S. aureus strains with the highest resistance to penicillins and III-IV generation cephalosporins have been isolated from the upper airways of healthy people. The ability to synthesize β-lactamases has been detected in 5 strains. It has been shown 32-fold decrease of MIC of penicillin for S. aureus 17 in the presence of studied hydrazone and Sn (IV) complex. Conclusions. Studied hydrazone and Sn (IV) complex have the potential ability to overwhelm the resistance of Gram-positive bacteria to β-lactam antibiotics.
Authors and Affiliations
O. Yu. Zinchenko, N. V. Shmatkova, I. Y. Seifullina, V. O. Lerer
Keywords
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- EP ID EP395804
- DOI 10.18524/2307-4663.2014.4(28).48424
- Views 127
- Downloads 0
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