Influence of Metronidazole on Oral Busulfan Test Dose
Journal Title: International Journal of Transplantation Research and Medicine - Year 2016, Vol 2, Issue 1
Abstract
Abstract: Individualization of busulfan (BU) dosing during pre-transplant conditioning for hematopoietic stem cell transplantation (HSCT) has been performed worldwide for more than a decade. The pharmacokinetic parameters of BU show high variability and studies report that high plasma concentrations (> 900 ng/mL) are associated with sinusoidal obstructive syndrome (SOS), whereas low plasma concentrations (< 600 ng/mL) are associated with graft rejection and/or disease recurrence.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP343415
- DOI 10.23937/2572-4045.1510019
- Views 147
- Downloads 0
B-Cell Targets to Treat Antibody-Mediated Rejection in Transplantation
Abstract: Antibody-mediated rejection (AMR) in allograft transplantation can be defined with a rapid increase in the levels of specific serological parameters after organ transplantation, presence of donor specific antib...
Disseminated Ochroconis in a Lung Transplant Recipient
Abstract: Ochroconis is a darkly pigmented "black mold", which is thermotolerant and found in soil as well as in decaying vegetables, hot springs, cave rocks and Paleolithic paintings. It is known to cause encephalitis i...
Pharmacological Conditioning of Brain Dead Donor Hearts with Erythropoietin and Glyceryl Trinitrate: Clinical Experience
Background:With the increasing success of heart transplantation, older and higher-risk donors and recipients are being accepted for transplantation. The risk of primary graft dysfunction (PGD) is thus increased. We inves...
Skin Lesions after Kidney Transplantation: An updated Review Including Recent Rare Cases
Skin disease is a significant cause of morbidity in chronically immunosuppressed patients, including organ transplant recipients. Cutaneous neoplasms are much more common in renal transplant recipients than in the genera...
Impact of Conditioning Including Anti-Thymocyte Globulin on Engraftment Kinetics and GvHD after Matched Related Allogeneic Stem Cell Transplantation
Background Graft-Versus-Host Disease (GvHD) remains a major complication of Allogeneic Stem Cell Transplantation (alloSCT). Anti-Thymocyte Globulin (ATG), however, reduces the incidence and severity of GvHD after alloSCT...