Influence of Plasma Cholesterol on Erythrocyte Membrane Cholesterol in Type 2 Diabetic Subjects
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 5
Abstract
Diabetes mellitus(DM) induced dyslipidemia results in various micro and macro vascular complications. It has been observed by many workers that the erythrocyte membrane cholesterol is elevated in DM which may lead to alterations in erythrocyte membrane characteristics As there is no proper cholesterol synthetic mechanisms available in mature erythrocytes, the raised membrane cholesterol might have originated from plasma cholesterol, as erythrocytes are continuously bathing in plasma. Hence a study was undertaken to assess the impact of plasma cholesterol concentration on the erythrocyte membrane cholesterol content. Diabetic as well as normal subjects of both sexes in the age group of 30-55 years were selected and a fasting heparinised blood sample was collected. Glucose and Cholesterol levels and the membrane cholesterol content of erythrocytes were estimated. The diabetic subjects were grouped into Group-1(plasma cholesterol <200mg/dl) and Group-2 (plasma cholesterol ≥200mg/dl). The results shows a significant elevation of erythrocyte membrane cholesterol (p<0.001) in diabetic subjects as well as a proportional raise in erythrocyte membrane cholesterol level in relation to plasma cholesterol concentration (Group-1: Plasma cholesterol 173.8±22.7mg/dl, Membrane cholesterol8.0± 3.57mg/cc; Group-2 Plasma cholesterol 341.1±14.43mg/dl, Membrane cholesterol 12.1± 4.43mg/cc) It is concluded from the present study that the plasma cholesterol level do influence erythrocyte membrane cholesterol concentration and higher the plasma cholesterol higher will be erythrocyte membrane cholesterol level.
Authors and Affiliations
Damini S P, Dr. Nagendra . S, Prashanthkumar Goudappala, Kashinath R T
Keywords
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- EP ID EP598170
- DOI 10.9790/0853-1605115256.
- Views 80
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