INFLUENCE OF SYNTHETIC ETHROGENES IN FOOD PRODUCTS ON THE DETOXICATION SYSTEM OF ANIMAL ANIMALS OF DIFFERENT AGE
Journal Title: Наукові доповіді НУБіП України - Year 2018, Vol 2, Issue 2
Abstract
The effect of synthetic estrogens on the state of peroxide oxidation of lipids and total antioxidant activity in animals of different ages in in vivo and in vitro have been investigated. In the analysis of data obtained during the effect of alimentary exogenous estrogen in kidneys and liver increase of peroxidation of lipids, the degree of which exceeded the activation of the antioxidant system was determined. In females in puberty, the reaction of the prooxidant system exceeded the force of response in organs of sexually mature animals. It can be assumed that such shifts can further become a trigger for reducing the potential of compensatory mechanisms in particular adaptation which is an important pathogenic link of the disease of the organs of excretion and detoxification. Exposure of synthetic estrogens in vitro led to the reduction of POL in female tissues in the puberty period and in the sexually mature rats by activating the antioxidant system by increasing thiol groups and agonist effects on enzymes. Violation of the sensitive balance between free radicals and antioxidants can lead to cell damage, which may indicate the existence of specific age-related physiological conditions determining high sensitivity to exogenous estrogen-like compounds.
Authors and Affiliations
T. Y. Lykholat, O. M. Marenkov, K. V. Yashchenko, E. S. Shaldyna, O. A. Lykholat
Keywords
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