Influence of thrombolytic therapy on early and long term leftventricular systolic function in patients with ST-segment elevation myocardial infarction
Journal Title: ZANCO JOURNAL OF MEDICAL SCIENCES - Year 2011, Vol 15, Issue 1
Abstract
Abstract Background and objectives: Left ventricular systolic dysfunction complicating acute myocardial infarction are responsible for significant morbidity and mortality. This study to assess the effect of thrombolytic therapy on the left ventricular systolic function during the first week and a year after ST- elevation myocardial infarction. Methods: In a study of 56 patients with first ST-Segment elevation myocardial infarction (42 men and 14 women; age range, 42-89 years (mean, 61 ± 10), who had been admitted to the Coronary Care Unit at Hawler Teaching Hospital from May 2008 to May 2009. study done to assess the left ventricular systolic function during the first week and first year after ST-elevation myocardial infarction. Twenty one patients received tissue plasminogen activator (Alteplase) 12 hour after the onset of symptoms labeled as group-I, the remaining patients (35), had no chance to receive thrombolytic therapy labeled as group II. Results: In group I the mean ejection fraction improved significantly from 51.6±9.4 during the first week to 55.14±11, P=0.034, at first year after acute myocardial infarction, while in group II there was no significant difference of mean ejection fraction during the first week (45.97±12.2) and first year of acute myocardial infarction (46.1±13.2),P=0.5. Conclusions: Thrombolytic therapy has a beneficial effect on left ventricular systolic function detected by echocardiography at the end of the first year of ST-elevation myocardial infarction Key words: Left ventricular systolic function.
Authors and Affiliations
Mohammed Hassan Alwan , Abdulkareem A. AL-Othman
Keywords
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