Influence of Various Schemes of Pathogenetic Treatment on the State of Prooxidant-Antioxidant Homeostasis on Patients with Acute Hepatitis B and Concomitant Use of Alcohol in Hepatotoxic Doses
Journal Title: Актуальна інфектологія - Year 2014, Vol 4, Issue 3
Abstract
The study involved 133 patients with acute hepatitis B aged from 18 to 60 years. The article shows that in patients with acute hepatitis B and concomitant chronic consumption of alcohol in hepatotoxic doses consumption, the height of disease is characterized by larger disturbances in prooxidant-antioxidant regulation due to the higher level of aldehyde phenylhydrazone of spontaneous oxidative modification of blood proteins and nitrites, which is combined with the low L-arginine content in blood serum. The period of convalescence in these patients is characterized by a higher level of aldehyde phenylhydrazones and ketone phenylhydrazones of spontaneous oxidative modification of blood proteins, a higher content of nitrites in combination with low L-arginine content in the blood serum, as compared with patients without concomitant liver disease. The use of L-arginine hydrochloride (Tivortin) and thiotriazoline in the treatment of patients with acute hepatitis B with chronic consumption of alcohol in hepatotoxic doses improves antioxidant-prooxidant processes by reducing the content of nitrites and ketone phenylhydrazones of spontaneous oxidative modification of blood proteins, increased content of L-arginine and catalase activity in blood serum, contributes to the normalization of alanine aminotransferase activity, and increased frequency of HBeAg — anti-HBe seroconversion compared with patients who are treated using only basic agents.
Authors and Affiliations
O. V. Rуabokon, O. O. Furyk, N. S. Ushenina
Keywords
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