INFORMATION TECHNOLOGIES IN CLINICAL AND PHARMACEUTICAL MANAGEMENT OF NEWBORN PATIENTS WITH ROTAVIRUS INFECTION: RETROSPECTIVE ANALYSIS
Journal Title: Annals of Mechnikov Institute - Year 2018, Vol 0, Issue 2
Abstract
Aim. A retrospective analysis of the effectiveness of pharmacotherapy of newborn patients with rotavirus infection using the developed information technology Materials and Methods. We proposed to evaluate therapy outcome based on survival analysis approach. Since cohort of patients has two available states: alive or dead, we proposed to use two states: hospitalized and discharged from hospital. Therefore, therapy effectiveness was associated with durations os stay in hospotal. For a certain cohort such effectiveness could be displayed as probablity curve of stay in hospital, so a lower curve reflexes higher intervention effectiveness. This could be graphically described as transmission of patients in a cohort between two states: hospitalized and discharged patients. Results. This approach was based on the developed computer program "Clinical and Pharmaceutical Management of Viral Infections" and tested with the use of 85 medical records for newborn babies from 5 to 60 days of life born in the period from 2001 to 2002 and came from maternity hospitals to the 1st and 2nd outbreaks of newborns and the intensive care unit of the NHSL "OKHMATDIT" mainly in a difficult condition: with clinical manifestations of gastrointestinal disorders, hypoxic or hypoxic-hemorrhagic lesions of the central nervous system, hyperbaric ilirubinemia, respiratory distress syndrome, etc. Analysis of medical records showed that all hospitalized patients were examined for RVI by the presence of rotavirus antigens in the clinical material (feces) by the indirect hemagglutination reaction method, the most accessible and widespread at that time in the laboratory. The principle of the method was that pretreated formalin or tannin erythrocytes (more often human or sheep), on the surface of which the specific antibodies are sorted, in the presence of a homologous antigen form aggregates, manifested by the phenomenon of agglutination. Among the patients studied proved positive 60 persons (70.6%), 32 of whom received basic pathogenetic therapy. The analysis showed that the onset of positive therapy outcomes for patients with RVI was longer, and therefore, it is more likely to remain in the hospital for the first 1 to 20 days of the disease. In a detailed analysis, both in all patients and only in patients with RVI, it was noted that the severity of the leading symptoms at the end of therapy was significantly reduced. However, the use of complex therapy with α2b-interferon was characterized by faster reverse development of clinical manifestations of the disease than in patients who did not receive interferon. In comparison, it was also investigated the use of smectites - antidiarrheal agents of natural or synthetic origin with sorption properties. The obtained results gave a confident ability to indicate their effectiveness, which was determined by a significant decrease in the probability curve of hospitalization days, both in the analysis of data of all patients and only in patients with RVI. Conclusion. The retrospective analysis using the developed IT showed that rectal application of recombinant α2b-interferon and smectites in the complex therapy of RVI in newborns can increase the clinical efficacy of therapy, namely, positively affect clinical manifestations of the disease through more rapid elimination of a number of symptoms. The results of the study prove that ICT based on pharmacoeconomic modeling can become an effective tool for clinical and pharmaceutical management of patients in a hospital, and is a reliable source for assessing the recovery rate, which is necessary to support decision-making by the doctor in choosing the optimal patient pharmacotherapy in real time.
Authors and Affiliations
S O. , Soloviov, O. V. , Kovaliuk, M. V. , Leleka, M. O. , Ivanov, I. V. Dzyublyk
Keywords
Related Articles
- EP ID EP612791
- DOI 10.5281/zenodo.1303964
- Views 221
- Downloads 0
NEW CODING SEQUENCES FORMATION BY VIRUSES WITH THE HELP OF HORIZONTAL TRANSFER AND GENE DUPLICATION
Besides the gene co-optation discusses in the previous article, viruses are able to form the cellular genome through horizontal gene transfer and by the copy number increase of the cellular genes with the help of amplifi...
PRIMARY MICROBIOLOGICAL SCREENING OF AMINO ACIDS AND THEIR MODIFIED VARIANTS
The primary microbiological screening of 20 native amino acids and 52 modified variants thereof was carried out. A significant antimicrobial activity was established for synthetic derivatives against reference strains of...
THE ROLE OF EPSTEIN-BARR VIRUS AND HUMAN ENDOGENOUS RETROVIRUSES IN THE PATHOGENESIS OF MULTIPLE SCLEROSIS
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS), the development of which is associated with the action of a large number of pathogenetic factors which role can vary sig...
IMMUNOPROPHYLAXIS OF PSEUDOMONOSIS: ACHIEVEMENTS AND PERSPECTIVES
The review article presents a retrospective analysis of attempts to develop effective vaccines for pseudomonas prophylaxis. P. aeruginosa vaccine has been sought for 40 years; however it is still not available. The incre...
SUBSTANTIATION OF OVERCOMING OF ANTIBIOTIC RESISTANCE IN ACINETOBACTER BAUMANNII CLINICAL STRAINS BY USAGE OF DECAMETHOXINUM
Introduction. Non-fermenting Gram-negative bacilli are known as one of the most frequent causative agents of hospital-acquired infections. Acinetobacter baumanii, as causative agent of infection complications of differen...