Inhibition of Mammary Gland Cancer Development by Propolis and Mangostin in Female Mice Balb/C
Journal Title: Journal of Mathematical and Fundamental Sciences - Year 2017, Vol 49, Issue 1
Abstract
The development of breast cancer involves many processes, including angiogenesis and metastasis. Some factors play a major role in angiogenesis, such as HIF-1α, and in metastasis, such as FAK and Wnt2. The aim of this study was to observe the effect of propolis and mangostin on the development of mammary gland cancer and on the expression of Wnt2 and FAK in Balb/C mice. Mammary gland tumors were induced in Balb/C mice by DMBA. The mice were divided into 5 treatment groups: negative control (K ); positive control treated with doxorubicin (14.04 mg/kg bw) (Dx); mice treated with propolis (0.32 mg/kg bw) (P) or mangostin (0.128 mg/kg bw) (M); and mice treated with a combination of propolis (0.32 mg/kg bw) and mangostin (0.128 mg/kg bw) (MP). Both mangostin and propolis did not affect the body weight of the mice. Treatment with propolis or treatment with propolis combined with mangostin was able to reduce tumor development activity in Balb/C mice. Moreover, the combination of mangostin and propolis was able to lower Wnt2, FAK and HIF-1α expression. It can be concluded that the combination of propolis and mangostin has potential to inhibit cancer development through downregulation of Wnt2, FAK, and HIF1α expression.
Authors and Affiliations
Marselina Irasonia Tan, Irham Hayati Irham Hayati
Keywords
Related Articles
- EP ID EP314892
- DOI 10.5614/j.math.fund.sci.2017.49.1.4
- Views 89
- Downloads 0
Magnetic Characterization of Sand and Boulder Samples from Citarum River and Their Origin
The Citarum River is a nationally strategic river located near Bandung, the capital city of West Java Province. The feasibility of using magnetic methods for monitoring pollution level is currently being tested in the ri...
On a Certain Subclass of Meromorphic Functions Defined by a New Linear Differential Operator
In this article, a new linear differential operator I^k (L_s^a (a_l,b_m )f(z)) is defined by using the Hadamard product of the q-hypergeometric function and a function related to the Hurwitz-Lerch zeta function. By using...
Flavonoid Compounds from the Herb of Krokot (Lygodium microphyllum) and their antioxidant activity against DPPH
Six flavonoid compounds, kaempferol (1), quercetin (2), acacetin (3), quercetin-3-O-β-D-glucopyranoside (4), kaempferol-3-O-β-D-glucopyranoside (5), and isorhamnetin-3-O-β-D-glucopyranoside (6), were isolated from the me...
Inclusion Properties of Orlicz and Weak Orlicz Spaces
In this paper we discuss the structure of Orlicz spaces and weak Orlicz spaces on R^n. We obtain some necessary and sufficient conditions for the inclusion property of these spaces. One of the keys is to compute the norm...
Optimal Vaccination and Treatment Schedules in a Deterministic Avian influenza Model
In this study, a transmission model of the Avian influenza disease was developed and analyzed in view of optimization of vaccination and medical treatment. The model is a host-vector model. We focussed on control of Avia...