Inhibitors of Sporangia Formation of Phytophthora capsici from Polygonum capitatum
Journal Title: Tropical Journal of Natural Product Research - Year 2018, Vol 2, Issue 7
Abstract
Received 21 June 2018 Revised 29 June 2018 Accepted 05 July 2018 Published online 08 July 2018 The genus Phytophthora comprises of nearly 120 pathogenic species which causes both economic and enviormental damage. This study aims to isolate active compounds from natural products for inhibition of sporangia formation of Phytophthora capsici. The ethyl acetate (EtOAc) layer of the methanol (MeOH) extract of Polygonum capitatum exhibited significant activity. The ethyl acetate (EtOAc) fraction was then subjected to bioassay-guided separation and purification to afford five active flavonoids which significantly inhibited sporangia formation on Phytophthora capsici. The structures were elucidated by spectroscopic analysis and comparison of spectroscopic data with those reported. The active compounds were identified as myricetin 7-O-α-Lrhamnopyranoside (1), quercetin 3-O-β-D-glucopyranoside (2), quercetin 4ʹ-O-α-Lrhamnopyranoside (3), quercetin 3-O-(2ʹʹ-galloyl)-α-L-rhamnopyranoside (4), and kaempferol 3O-α-L-rhamnopyranoside (5). Compounds 1, 2, and 3 were isolated from P. capitatum for the first time. Moreover, the stereo structure of sugar moiety of 3 was corrected by chemical derivatization means. Compounds (1-5) isolated from P. capitatum significantly inhibited sporangia formation of Phytophthora capsici.
Authors and Affiliations
Umer Farooq, LiHong Cheng, Qian Wang, Yuan Chao Wang, Hirokazu Kawagishi, JianHua Qi
Keywords
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- EP ID EP494735
- DOI 10.26538/tjnpr/v2i7.10
- Views 57
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