Inhibitory effect of newly-synthesized chalcones on hemolytic activity of methicillin-resistant Staphylococcus aureus
Journal Title: Polish Journal of Microbiology - Year 2015, Vol 64, Issue 4
Abstract
Pathogenicity of methicillin-resistant [i]Staphylococcus aureus [/i](MRSA) is associated with a broad spectrum of virulence factors, amongst which is α-hemolysin. The aim of this study was to investigate the effect of three newly-synthesized chalcones (1,3- Bis-(2-hydroxy-phenyl)-propenone, 3-(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone) on α-hemolysin production of clinical isolates of MRSA. Subinhibitory concentrations of the tested compounds reduced hemolytic activity of MRSA strains, with almost complete abolishment of hemolysis at concentrations in the range of 1/2–1/4 x MIC (25–12.5 μg/ml). In conclusion, newly-synthesized chalcones tested in this study showed potent inhibitory activity on α-hemolysin production of multiresistant and genetically diverse MRSA strains.
Authors and Affiliations
Dragana D. Bozic, Marina T. Milenkovic, Branka M. Ivkovic, Anders Larsen, Ivana B. Cirkovic
Keywords
Related Articles
- EP ID EP81173
- DOI -
- Views 91
- Downloads 0
<strong>Nodulation Competitiveness of <em>Ensifer meliloti</em> Alfalfa Nodule Isolates and Their Potential for Application as Inoculants</strong>
Alfalfa ([i]Medicago sativa[/i]) is widely cultivated legume, which enters into nitrogen-fixing symbiosis with [i]Ensifer[/i] ([i]Sinorhizobium[/i]) spp. In this study, autochthonous rhizobial population of [i]Ensifer [/...
In Vitro Studies of Antibacterial and Antifungal Wound Dressings Comprising H<sub>2</sub>TiO<sub>3</sub> and SiO<sub>2</sub> Nanoparticles
The incidence rate of the infected and complex wound is established approximately 40 000/1 million of the world’s adult population. The aim of this study was to assess the efficiency of three novel types of wound dr...
Intestinal Microbiota, Obesity and Prebiotics
Over the past few decades there has been a significant increase in the prevalence of obesity in both children and adults. Obesity is a disease that has reached epidemic levels on a global scale. The development of obesit...
Intracellular Siderophore Detection in an Egyptian, Cobalt-Treated F. solani Isolate Using SEM-EDX with Reference to its Tolerance
An Egyptian, plant pathogenic Fusarium solani isolate was grown on cobalt concentrations of 0, 50, 200, 500, 800, and 1000 ppm. The isolate survived concentrations up to 800 ppm, however failed to grow at 1000 ppm. Morph...
Biochar-Rhizosphere Interactions – a Review
Biochar is a solid material of biological origin obtained from biomass carbonization, designed as a mean to reduce greenhouse gases emission and carbon sequestration in soils for a long time. Biochar has a wide spectrum...