Inhibitory effect of newly-synthesized chalcones on hemolytic activity of methicillin-resistant Staphylococcus aureus
Journal Title: Polish Journal of Microbiology - Year 2015, Vol 64, Issue 4
Abstract
Pathogenicity of methicillin-resistant [i]Staphylococcus aureus [/i](MRSA) is associated with a broad spectrum of virulence factors, amongst which is α-hemolysin. The aim of this study was to investigate the effect of three newly-synthesized chalcones (1,3- Bis-(2-hydroxy-phenyl)-propenone, 3-(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone) on α-hemolysin production of clinical isolates of MRSA. Subinhibitory concentrations of the tested compounds reduced hemolytic activity of MRSA strains, with almost complete abolishment of hemolysis at concentrations in the range of 1/2–1/4 x MIC (25–12.5 μg/ml). In conclusion, newly-synthesized chalcones tested in this study showed potent inhibitory activity on α-hemolysin production of multiresistant and genetically diverse MRSA strains.
Authors and Affiliations
Dragana D. Bozic, Marina T. Milenkovic, Branka M. Ivkovic, Anders Larsen, Ivana B. Cirkovic
Keywords
Related Articles
- EP ID EP81173
- DOI -
- Views 75
- Downloads 0
Prevalence of Parasitic Contamination in Salad Vegetables Collected from Supermarkets and Street Vendors in Amman and Baqa’a – Jordan
One of the main ways in transmitting parasites to humans is through consuming contaminated raw vegetables. The aim of this study was to evaluate the prevalence of parasitological contamination (helminthes eggs, [i]Giardi...
Antimicrobial Activity of Penicillin G and N-acetylcystein on Planktonic and Sessile Cells of Streptococcus suis
The aim of this study was to investigate the capacity of [i]Streptococcus suis [/i]strains to form biofilms and to evaluate the antimicrobial activity of Penicillin G and N-acetylcystein (NAC) on both [i]S. suis[/i] sess...
Metallo-Beta-Lactamase Producing Pseudomonas aeruginosa in a Healthcare Setting in Alexandria, Egypt
Pseudomonas aeruginosa has emerged as a major healthcare associated pathogen that creates a serious public health disaster in both developing and developed countries. In this work we aimed at studying the occurrence of m...
Isolation and characterization of ;Streptomycetes with plant growth promoting potential from mangrove ecosystem
A total of 66 actinomycetes isolates were isolated from mangroves of Andhra Pradesh, India, using various enrichment techniques and pre-treatments. The samples were collected from Coringa mangrove ecosystem and pre-...
<strong>Relationship between <em>ure</em>B Sequence Diversity, Urease Activity and Genotypic Variations of Different <em>Helicobacter pylori</em> Strains in Patients with Gastric Disorders</strong>
Association of the severity of[i] Helicobacter pylori [/i]induced diseases with virulence entity of the colonized strains was proven in some studies. Urease has been demonstrated as a potent virulence factor for [i]H. py...