Inhibitory effect of newly-synthesized chalcones on hemolytic activity of methicillin-resistant Staphylococcus aureus
Journal Title: Polish Journal of Microbiology - Year 2015, Vol 64, Issue 4
Abstract
Pathogenicity of methicillin-resistant [i]Staphylococcus aureus [/i](MRSA) is associated with a broad spectrum of virulence factors, amongst which is α-hemolysin. The aim of this study was to investigate the effect of three newly-synthesized chalcones (1,3- Bis-(2-hydroxy-phenyl)-propenone, 3-(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone) on α-hemolysin production of clinical isolates of MRSA. Subinhibitory concentrations of the tested compounds reduced hemolytic activity of MRSA strains, with almost complete abolishment of hemolysis at concentrations in the range of 1/2–1/4 x MIC (25–12.5 μg/ml). In conclusion, newly-synthesized chalcones tested in this study showed potent inhibitory activity on α-hemolysin production of multiresistant and genetically diverse MRSA strains.
Authors and Affiliations
Dragana D. Bozic, Marina T. Milenkovic, Branka M. Ivkovic, Anders Larsen, Ivana B. Cirkovic
Keywords
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