Instability of Cefpodoxime Proxetil Oral Suspension at Different Temperature Storage Conditions
Journal Title: Journal of Pharmaceutics & Pharmacology - Year 2017, Vol 5, Issue 1
Abstract
The advantages of oral dosage form over other dosage forms are responsible for its popularity which includes its ease of administration, patient compliance and stability of the formulation. This study compared the stability of three Cefpodoxime proxetil products available in Nigeria market at fridge temperatures (2-8 °C), room temperature (25 °C) and elevated temperature (42 °C). Flow properties, rheological and the physicochemical parameters of both powder and reconstituted powder were used to evaluate the stability of different brands of Cefpodoxime proxetil available in Nigeria. This study shows that the potencies of all the reconstituted samples stored at 25 °C were within the specified standard range within the evaluating period of 90 days, while the potencies of those samples under refrigerated condition were within the specified standard range within the evaluating period of 14 days. For powdered samples, there was a considerable loss of potencies (<85%) at elevated temperature (42 °C) in all the samples after day 60. Physicochemical evaluation also agrees with the outcome of the drug assay for all the samples except Tambac® which deviated from specification as from day 14. The study therefore emphasizes the need for the storage of both reconstituted and un-reconstituted suspensions at refrigerated and temperature less than 25 °C.
Authors and Affiliations
Abayomi Omotoso Ebenezer
Keywords
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- EP ID EP485461
- DOI 10.13188/2327-204X.1000022
- Views 102
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