INTEGRAL ASSESSMENT OF FACTORS AFFECTING THE EFFECTIVENESS OF ACCOMPANYING IMMUNOTHERAPY IN ONCOGYNECOLOGICAL PATIENTS
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2018, Vol 5, Issue 9
Abstract
According to our data, the overall 5-year survival rates in patients with cervical cancer II-III stages after complex therapy in combination with immunotherapy were as follows: in the group of patients receiving EIPT without plasmapheresis - 68.3 ± 5.4% (P = 0.037), in the group of patients receiving EIPHT with preliminary plasmapheresis - 72.3 ± 5.1% (P = 0.041) and in the control group without immunotherapy - 59.2 ± 4.2%. The parameters of the overall 5-year survival in patients with stage II-III ovarian cancer were: in the group receiving EIPHT without plasmapheresis - 72.1 ± 4.9% (P = 0.036), in the group receiving EIPHT with plasmapheresis - 73.5 ± 5.32% (P = 0.043) and in the control group without immunotherapy - 62.6 ± 5.0%. The analysis of the correlation of the tumor markers level and 5-year survival of patients allows to conclude that the positive level of p53, VEGF and Ki-67 in patients with cervical cancer and ovarian cancer, along with high proliferative activity of the tumor, may serve as a basis for this the category of patients accompanying immunotherapy with EIPHT, which can significantly increase the effectiveness of standard antitumor treatment regimens. At a positive level of oncomarkers, along with high proliferative activity of the tumor, it is possible to recommend carrying out accompanying immunotherapy with EIPHT with plasmapheresis.
Authors and Affiliations
Kamyshov S. V.
Keywords
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