Intense and exhaustive exercise induce oxidative stress in skeletal muscle
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2011, Vol 1, Issue 1
Abstract
Objective: To assess the oxidative stress and antioxidant defense system in the skeletal muscle of male albino rats subjected to strenuous exercise programme. Methods: Wistar strain albino rats were subjected to exhaustive swimming exercise programme daily for a period of five days. The thiobarbituric acid reactive substances (TBARS), conjugated dienes, superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase were measured in the gastrocnemius muscle of the exercised animals. Results: The elevated levels of TBARS and conjugated dienes indicated the oxidative stress in the gastrocemius muscle of the exercised animals. The depleted activity levels of superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase in the exercise animals indicated the increased oxidative stress and decreased antioxidative defense system in the muscle. Conclusions: The study suggests that prolonged strenuous exercise programme can induce oxidative stress and therefore an optimal level of exercise schedule should be advocated to obtain the maximum benefit of exercise programme.
Free radical scavenging and antioxidant activity of D-pinitol against 7, 12 dimethylbenz(a) anthracene induced breast cancer in sprague dawley rats
Objective: To investigate whether D-pinitol efficiently scavenge free radicals using various in vitro models [1, 1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide, superoxide anion and total antioxidant activity] and in v...
Iron deficiency anaemia associated with helminths and asymptomatic malaria infections among rural school children in Southwestern Nigeria
Objective: To estimate the relative contribution of causes of anaemia in the rural communities and evaluate the association between parasitic infections and anaemia. Methods: A total of 292 blood and stool samples of age...
Thalassemia: Impact of consanguineous marriages on most prevalent monogenic disorders of humans
Thalassaemia is an inherited autosomal recessive disorder closely associated with consanguineous marriages. A literature search was conducted with an aim to investigate thalassemia and consanguineous marriages. Articles...
In vitro, in vivo evaluation of inter polymer complexes between carboxymethyl fenugreek gum and chitosan or carboxymethyl guar gum and chitosan for colon delivery of tamoxifen
Objective: To develop colon targeted tamoxifen tablets employing interpolymer complexes (IPC) between carboxymethyl fenugreek gum (CMF) and chitosan (CH) or carboxymethyl guar gum (CMG) and CH. Methods: IPC between CMF a...
Brain cystogenesis capacity of Toxoplasma gondii, avirulent Tehran strain in mice
Objective: To investigate the brain cystogenesis capacity of Tehran strain of Toxoplasma gondii (T. gondii) that had been isolated from a patient with lymphadenitis in 1973. Methods: A volume of 0.5 mL mice brain suspens...