Interaction of dexmedetomidine combined with sufentanil in the treatment of adenomyopathy by high-intensity focused ultrasound
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 12
Abstract
Objective To explore the interaction and compatibility optimization of dexmedetomidine combined with sufentanil in treatment of adenomyosis by high-intensity focused ultrasound (HIFU). Methods A total of 96 patients with adenomyosis who underwent HIFU treatment in Affiliated Hospital of Shandong Second Medical University from January 2023 to December 2023 were selected as the study subjects, and were randomly divided into 12 groups, with 8 cases in each group. The pain relief score (VAS score) and sedation score (Ramsay score) of the patient were recorded before surgery, 30 minutes after surgery began, and immediately after surgery. The changes of patients’ heart rate (HR), mean arterial pressure (MAP) and saturation of peripheral oxygen (SpO2) were monitored. The isobolographic analysis method was used to analyze the interaction between the two drugs at bispectral index for half of the patients falling asleep (BIS50). The response curve model was used to analyze the interaction law and optimal compatibility concentration range between dexmedetomidine and sufentanil, with the goal of 95% patients being satisfied with analgesia and Ramsay being effective in sedation. Results The response curve model showed that dexmedetomidine and sufentanil had a synergistic effect in the HIFU treatment of adenomyosis. When sufentanil concentration was 0.30, 0.40 and 0.45 μg/kg respectively, the optimal concentration range of dexmedetomidine was 0.53 to 0.65, 0.48 to 0.60 and 0.44 to 0.57 μg/kg respectively. Conclusion Dexmedetomidine and sufentanil have a synergistic effect on analgesia, and when used within the optimal compatibility concentration range, it can not only effectively relieve analgesia, but also reduce the occurrence of adverse reactions.
Authors and Affiliations
LI Guanrong, LI Min, WANG Ying, SUN Yingui
Keywords
Related Articles
- EP ID EP753806
- DOI 10.13429/j.cnki.cjcr.2024.12.010
- Views 8
- Downloads 0
Prognosis of 111 young patients with hypertensive intracerebral hemorrhage: a single center clinical study
<b>Objective</b> To explore the differences in prognosis of young hypertensive intracerebral hemorrhage (HIH) patients with different age, gender, and bleeding sites. <b>Methods</b> A retrospective analysis of 111 young...
Evaluation of the influence of atlantoaxial transverse ligament on stability of atlantoaxial complex fracture using 3D finite element method
<b>Objective</b> To analyze and compare the effects of transverse ligament injury on the stability and stress distribution of atlantoaxial complex fractures using 3D finite element method. <b>Methods</b> A male volunte...
Genetic causes of isolated congenital heart disease
The genetic mechanism of congenital heart disease (CHD) is complex and currently lacks a clear understanding. Literature studies on CHD often report the presence of concurrent extracardiac anomalies, but since the majori...
Effect of esketamine combined with serratus anterior plane block on postoperative analgesia after modified radical mastectomy for breast cancer
Objective To explore the effects of esketamine combined with serratus anterior plane block (SAPB) on postoperative analgesia, anxiety and depression in patients with breast cancer undergoing modified radical mastectomy....
Short-term placement of F3 catheter after ureteroscopy and holmium laser lithotripsy for lower ureteral calculi
Objective To compare the clinical effects of short-term placement of F3 catheter and conventional placement of double-J stent after ureteroscopic holmium laser lithotripsy for lower ureteral calculi. Methods A total of 6...