Abstract

Two chiral bridge-substituted manganese(III) complexes [Mn(III)L]+Cl (L=N,N’- bis-(2　-hydroxynaphthalene-1-carbaldehyde)-(1R,2R)-(-)-diaminocyclohexane (R) and N,N’-bis-(2-hydroxynaphthalene-1-　carbaldehyde)-(1S,2S)-(+)-diaminocyclohexane (S)) are synthesized. The interaction of these complexes with calf thymus DNA is investigated by spectroscopic and viscosity measurements. Results of spectroscopic and viscosity measurements suggest that the two complexes bind to DNA via an intercalative mode and display enantioselectivity. These Mn(III) complexes are found to promote the cleavage of plasmid DNA pBR322 in the presence of H2O2.

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