Interaction of phospholipase enzymes with autophagic processes; importance for cell signaling and therapeutics
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2017, Vol 6, Issue 3
Abstract
Phospholipases are inherently involved in signalling mechanisms of various neurotransmitters and hormones. Cytosolic phospholipase (cPLA2) initiates pro-inflammatory lipid mediator pathways which play a critical role in host defense and in inflammation. The crosstalk between the two pathways remains unclear. In this article, the important roles of the three phospholipases i.e PLC, PLD and PLA2 are investigated in the autophagic processes and their link to intracellular kinetics of signalling molecules. While autophagy delivers cytoplasmic constituents to autophagosomes and is involved in innate and adaptive immunity. The cPLA2 and its metabolite lipid mediators have been shown to induce autophagy in the macrophage cell line and in primary monocytes. Cysteinyl leukotrienes D4 and E4 and PGD2 also induced these effects. The autophagy is independent of changes in mTOR or autophagic flux. cPLA2 and lipid mediator-induced autophagy is ATG5 dependent. These data suggest that lipid mediators seem to play a role in the regulation of autophagy, demonstrating a connection between the two seemingly separate innate immune responses, induction of autophagy and lipid mediator generation.
Authors and Affiliations
Manoj G Tyagi, Kapil D Sagar, K Arumugasamy, Divya V, Joyce Nirmala
Keywords
Related Articles
- EP ID EP3849
- DOI -
- Views 431
- Downloads 21
Serofrecquancy of Human Immuno Deficiency virus among Known hepatitis Bvirus infected patients attending Talodihospital, SouthkordofanState, Sudan
Background: Co infection with human immuno deficiency virus (HIV) and hepatitis B virus (HBV) is common; worldwide, an estimated 10% of HIV-infected persons have chronic hepatitis B; because The incidence of traditional...
Pharmacological and Phytochemical Screenings of Ethanol Extract of Sterculia villosa Roxb.
The antimicrobial, anti-inflammatory, membrane stabilization and anti-atherothrombosis activities of crude ethanol extract of leaves of Sterculia villosa Roxb. has been investigated. In antimicrobial assay by disc diffus...
ANAYTICAL METHOD DEVEOPMENT AND VAIDATION OF BUTYLATED HYDROXYTOLUENE IN ROSUVASTATIN TABLETS BY USING RP-HPLC
An RP-HPLC method was developed and validated for the estimation of Butylated Hydroxy toluene in Rosuvastatin Tablets. The chromatographic system was equipped with Hypersil BDS, C18, 250 X 4.6 mm, internal diameter with...
Evaluation of Microbial Contamination of Eye Make up Product: Mascara
Eyes are one of the most important features when it comes to beauty. Various cosmetics are used to enhance their level of attractiveness like mascaras, eyeliners eye shadow among many more. Out of these above products ma...
PHARMACOMETRIC BASED DESIGN AND ANALYSIS BRIDGING THE GAP FOR PEDIATRIC CLINICAL TRIALS
A major test is recognizing, enrolling, and enlisting patients. The accessible pool of kids for target implications is much littler than grown-ups, and moral stipulations essentially restrict the amount of participants.