Interactions of excitatory amino acid receptor antagonists with antiepileptic drugs in three basic models of experimental epilepsy.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 5
Abstract
Successful management of epilepsy still remains a vital problem. Despite using various combinations of antiepileptic drugs (AEDs), 20-25% of epileptic patients are insensitive to currently available medication. Therefore, there is a considerable need for finding a more effective AED or synergistic combinations of AEDs. Experimental and clinical data indicate that excitatory amino acid (EAA) receptor antagonists possess anticonvulsant potential. Moreover, EAA antagonists can potentiate the protective action of conventional AEDs. Unfortunately, not all beneficial (in terms of anticonvulsant activity) combinations may be recommended since some of them produce significant adverse effects which restrict their clinical use. The aim of this review was to assemble current literature data on interactions of EAA receptor antagonists with conventional AEDs. Generally, N-methyl-D-aspartate (NMDA) receptor antagonists combined with AEDs produce significant adverse effects. Non-NMDA receptor antagonists represent a more promising group.
Authors and Affiliations
Katarzyna Wojtal, Kinga Borowicz, Barbara Błaszczyk, Stanisław Czuczwar
Keywords
Related Articles
- EP ID EP128820
- DOI -
- Views 87
- Downloads 0
Effects of angiotensin-converting enzyme inhibitors beyond lowering blood pressure - are they important for doctors?
Large clinical trials and experimental studies have indicated that not all of the beneficial properties of angiotensin-converting enzyme inhibitors (ACE-Is) can be attributed to the lowering of blood pressure. The aim of...
Effects of three calcium channel antagonists (amlodipine, diltiazem and verapamil) on the protective action of lamotrigine in the mouse maximal electroshock-induced seizure model.
The aim of this study was to assess the effect of three calcium channel antagonists (amlodipine, diltiazem and verapamil) on the anticonvulsant action of lamotrigine (a second generation antiepileptic drug) against maxim...
Effect of total and partial nephrectomy on the elimination of ciprofloxacin in humans.
Background: Renal cell carcinoma (RCC) is the most common form of kidney cancer. Surgery is a standard procedure to resect the tumor during total (TN) or partial (nephron-sparing) nephrectomy (PN). Ciprofloxacin is most...
Activation of orexin/hypocretin type 1 receptors stimulates cAMP synthesis in primary cultures of rat astrocytes.
The effects of orexins, which are also named hypocretins, on cAMP formation were examined in primary cultures of rat astrocytes. Orexin A, an agonist of OX(1) and OX(2) receptors, stimulated cAMP production with an EC(50...
Epicutaneous immunization with myelin basic protein protects from the experimental autoimmune encephalomyelitis.
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS) with limited treatment modalities. One of the experimental methods that protect from autoimmune diseases is oral to...