Interactions of levetiracetam with ethosuximide in the mouse 6 Hz psychomotor seizure model – a type II isobolographic analysis
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2014, Vol 8, Issue 2
Abstract
The aim of the present study was to characterize the anticonvulsant effects of levetiracetam in combination with ethosuximide in the mouse 6 Hz psychomotor seizure model. Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes; type II isobolographic analysis was used to characterize the consequent anticonvulsant interactions between the drug combinations for fixed-ratios of 1:1, 1:2, 1:5 and 1:10. With type II isobolographic analysis, the combinations of levetiracetam with ethosuximide for the fixed-ratios of 1:5 and 1:10 were supra-additive (synergistic; P<0.05 and P<0.01, respectively) in terms of seizure suppression, while the combinations for the fixed-ratios of 1:1 and 1:2 were additive in the mouse 6 Hz psychomotor seizure model. The combinations of levetiracetam with ethosuximide for the fixed-ratios of 1:5 and 1:10 appear to be particularly favorable combinations exerting supra-additive interaction in the mouse 6 Hz psychomotor seizure model. Finally, it may be concluded that because of the synergistic interactions between levetiracetam and ethosuximide, the combination might be useful in clinical practice.
Authors and Affiliations
Jarogniew J. Łuszczki, Aleksandra Wlaź, Maria Kondrat-Wróbel, Daniel Pyrka, Magdalena Florek-Łuszczki
Keywords
Related Articles
- EP ID EP58816
- DOI -
- Views 167
- Downloads 0
Can deep vein thrombosis be predicted after varicose vein operation in women in rural areas?
[b]Introduction[/b]. Chronic venous disease is a group of symptoms caused by functional and structural defects of the venous vessels. One of the most common aspects of this disease is the occurrence of varicose veins. Th...
Risk assessment of accidental exposure of surgeons to blood during orthopedic surgery. Are we safe in surgical gloves?
Aim. To analyze tears in sterile surgical gloves used by surgeons in the operating theatre of the Trauma and Orthopedic Surgery Department, Copernicus Memorial Hospital, Łódź, PolandMaterials and Method. This study analy...
Level and determinants of physical activity among school adolescents in Poland
The recognition of adolescents’ physical activity has become one of the serious challenges of the modern times, as a concern about the future health of societies. The major goal of the presented study was to discover the...
Depressive episodes and depressive tendencies among a sample of adults in Kielce, south-eastern Poland
Introduction and Objectives: Previous community research has shown differences in depression and depressive symptoms across different socioeconomic and demographic groups. However, very few population-based studies on de...
Progress in the molecular methods for the detection and genetic characterization of Cryptosporidium in water samples.
Cryptosporidium, the protozoan parasite, has several transmission routes, including anthroponotic and zoonotic transmission, as well as the foodborne way, but mainly by water. The oocysts, the resistant stage produced by...