Interactions of levetiracetam with ethosuximide in the mouse 6 Hz psychomotor seizure model – a type II isobolographic analysis
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2014, Vol 8, Issue 2
Abstract
The aim of the present study was to characterize the anticonvulsant effects of levetiracetam in combination with ethosuximide in the mouse 6 Hz psychomotor seizure model. Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes; type II isobolographic analysis was used to characterize the consequent anticonvulsant interactions between the drug combinations for fixed-ratios of 1:1, 1:2, 1:5 and 1:10. With type II isobolographic analysis, the combinations of levetiracetam with ethosuximide for the fixed-ratios of 1:5 and 1:10 were supra-additive (synergistic; P<0.05 and P<0.01, respectively) in terms of seizure suppression, while the combinations for the fixed-ratios of 1:1 and 1:2 were additive in the mouse 6 Hz psychomotor seizure model. The combinations of levetiracetam with ethosuximide for the fixed-ratios of 1:5 and 1:10 appear to be particularly favorable combinations exerting supra-additive interaction in the mouse 6 Hz psychomotor seizure model. Finally, it may be concluded that because of the synergistic interactions between levetiracetam and ethosuximide, the combination might be useful in clinical practice.
Authors and Affiliations
Jarogniew J. Łuszczki, Aleksandra Wlaź, Maria Kondrat-Wróbel, Daniel Pyrka, Magdalena Florek-Łuszczki
Keywords
Related Articles
- EP ID EP58816
- DOI -
- Views 140
- Downloads 0
Occupational injury rates in personnel of emergency medical services
[i][/i][b]Introduction and objectives. [/b]The system of emergency medical services (EMS) in Poland was established in 2006. The risk of occupational injuries to EMS personnel is very high, irrespective of the country wh...
Comparison of indicators of the use of insulin and oral diabetes medication in a Polish population of patients in urban and rural areas in the years 2008, 2011 and 2012
introduction. Diabetes is one of the 10 most important chronic diseases in the world. According to the data of the International Diabetes Federation, in Poland 9% of the population between the ages of 20–79 suffer from d...
Occurrence of [i]Leptospira[/i] DNA in water and soil samples collected in eastern Poland
[i]Leptospira[/i] is an important re-emerging zoonotic human pathogen, disseminated by sick and carrier animals, water and soil. Weather calamities, such as flooding or cyclones favour the spreading of these bacteria. To...
Coupling forces resulting from the type of chain saw used
Introduction. Woodcutters’ working conditions are difficult due to the presence of numerous occupational hazards. Petrol –fuelled chain saws commonly used in forestry produce vibration, which may lead to the development...
The level of health education in the Polish population
Background: The study assessed factors influencing awareness of Poles concerning lifestyle factors that affect development of obesity, type 2 diabetes and cardiovascular diseases (CVD). Methods: A questionnaire survey...