Disturbance of posture in children with very low lead exposure, and modification by VDR FokI genotype
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2014, Vol 21, Issue 4
Abstract
[b]Introduction and objective[/b]. Lead has a negative effect on the central nervous system (CNS), [i]inter alia [/i]indicated by disturbance of posture. However, knowledge of the CNS effects at low exposure is insufficient. Individuals differ in vulnerability, possibly because of genetic predisposition. Polymorphisms in the δ-aminolevulinic acid dehydratase (ALAD) and vitamin D receptor (VDR) genes may modify lead metabolism and neurotoxicity. The objective of the study was to determine whether very low lead exposure affects posture in children, and whether ALAD and VDR genotypes modify the effect. Materials and methods. In 1996–2001, 108 (age 5–13, mean 6.9), and in 2008–2010 231 (age 5–11, mean 7.9) children from Poland were tested by posturography and blood-lead concentration (B-Pb; medians 50 and 36 µg/L, respectively). The children were genotyped for ALAD ([i]RsaI, MspI[/i]) and VDR ([i]FokI, BsmI, TaqI[/i]). [b]Results[/b]. There were correlations between posture and B-Pb (sway area with closed eyes: rS=0.24, P<0.001; velocity: rS=0.21, P<0.001). Significant effects (adjusted for the potential confounders height and mother´s education) were present already at (ln-transformed) B-Pb <50 µg/L [β (regression coefficient) for sway area 0.025, p=0.001), and even stronger than at higher levels (β=0.006, p=0.06, respectively)]. The ff carriers in VDR FokI polymorphism were more susceptible to the effect of lead on the balance system, while other VDR or ALAD genotypes did not significantly modify the effect. [b]Conclusions[/b]. Effects on CNS, as reflected by disturbances of posture, were present at very low lead exposure (B-Pb <50 µg/L), and the effect was significantly greater at such low B-Pbs than at higher. VDR FokI significantly modified the effect.
Authors and Affiliations
Natalia Pawlas, Karin Broberg, Staffan Skerfving, Krystyna Pawlas
Keywords
Related Articles
- EP ID EP80872
- DOI -
- Views 151
- Downloads 0
Comparison of farmers workload by manual and mechanical tasks on family farms
The aim of this study was to compare the workload between tasks undertaken manually and those with the assistance of mechanical devices. The results indicate that the workload during the tasks assisted by mechanisation w...
Bioaerosol assessment in naturally ventilated historical library building with restricted personnel access
The aim of this study was to check the degree and identify the sources of microbial contamination of the Jasna Góra (Bright Hill) monastery library 10 years after disinfection of the incunabula collection. The registered...
The role of weight training in treating farmers with lumbar discopathy
Introduction: Weight training can have a very positive impact on the body by improving both the functioning of internal organs and motor coordination. Weakening of the muscles leads to spinal pain, which in turn reduces...
Meteorological parameters and severity of acute pulmonary embolism episodes.
Frequency of acute pulmonary embolism episodes has been previously shown to correlate significantly with meteorological factors in the period preceding their occurrence. The purpose of the study was to analyze the relati...
Etiopathogenesis of midfacial fractures in patients treated at Maxillofacial Surgery Clinic , Medical University of Lublin in 2007–2011
[b]Introduction:[/b] With the growing industrialization and the increasingly rapid pace of life the number and variety of injuries are growing higher. In the midst of injuries, the midfacial injuries constitute a conside...