INTERCONNECTION BETWEEN THE KALLIKREIN-KININ SYSTEM AND ENDOGENOUS INTOXICATION OF RATS OF DIFFERENT AGE IN THE CONDITIONS OF THE EARLY AND LATE POLYTRAUMA
Journal Title: Наукові доповіді НУБіП України - Year 2018, Vol 2, Issue 2
Abstract
The interrelation between the kallikrein - kinin system (KKS) and endogenous intoxication (EI) in the early and late terms after the polytrauma modeling was examined. The research was conducted with 156 non- linear white rats at the age of 3, 6 and 24 months by polytrauma modeling. The material for biochemical research was taken at 1, 3, 24 hour and 14 day after injury. Activation of KKS confirms the presence of inflammatory process in animals with polytrauma. After polytrauma modeling of all examined age groups of animals, the increase of specific proteolysis by the Kallikrein (KK) can indicate the activation of adaptive protective reserves. With age, there is a slight exhaustion of nocifensor. The growth of the medium-weight molecules content of the animal organism after the polytrauma modeling indicates an increase in catabolic processes. Increasing the content of MWM254 may indicate the hepatocyte membranes failure, and MWM280 - an inhibition of detoxification function of the liver. Activation of the examined parameters confirms the presence of inflammatory process in animals with polytrauma, and there is a tendency to its greater increase in young animals. Data were obtained in favor of stable activation of total proteolysis in mature and elderly animals.
Authors and Affiliations
S. R. Pidruchna, H. M. Stepanova
Keywords
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