Interleukin-1 (IL-1) in stress-induced activation of limbic-hypothalamic-pituitary adrenal axis.
Journal Title: Pharmacological Reports - Year 2010, Vol 62, Issue 6
Abstract
Proinflammatory cytokine interleukin-1 (IL-1) produced during psychological and immunological stress, plays a significant role in the neuroendocrine and stress responses. Brain IL-1 is an important mediator in stress-induced stimulation of the limbic-hypothalamic-pituitary-adrenal axis and secretion of ACTH and corticosterone. This review aims to describe some signaling pathways between the limbic-hypothalamic-pituitary structures during prolonged stress responses including their sensitization and adaptation. Interleukin-1 represents an important central component operating in neurochemical and immune network for efficient coping in preventing stress-associated psycho- and neuropathology.
Authors and Affiliations
Anna Gądek-Michalska, Jan Bugajski
Keywords
Related Articles
- EP ID EP85278
- DOI -
- Views 91
- Downloads 0
Influence of long-term administration of rutin on spatial memory as well as the concentration of brain neurotransmitters in aged rats.
Background: The present study was designed to investigate the behavioral and neurochemical effects of long-term oral rutin administration to old male WAG rats (100 and 200 mg/kg b.w./day). Rutin is a well-known dietary f...
Influence of zinc supplementation on imipramine effect in a chronic unpredictable stress (CUS) model in rats.
Zinc is an endogenous modulator of neuronal activity and may play an important role in the pathogenesis of depression. Recent studies have shown that zinc exhibits antidepressant-like activity in some models of depressio...
Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron.
The risk of cardiotoxicity is the most serious drawback to the clinical usefulness of anthracycline antineoplastic antibiotics, which include doxorubicin (adriamycin), daunorubicin or epirubicin. Nevertheless, these comp...
Maternal immune activation leads to age-related behavioral and immunological changes in male rat offspring - the effect of antipsychotic drugs.
Prenatal immune system disturbances have been postulated to play an important role in pathogenesis of schizophrenia and related disorders. In the present study, we sought to answer the question whether behavioral changes...
Influence of bupropion and calcium channel antagonists on the nicotine-induced memory-related response of mice in the elevated plus maze.
In this study, we investigated the effects of acute administration of nicotine on memory-related behavior in mice using the elevated plus maze test. In this test, the time necessary for mice to move from the open arm to...