Maternal immune activation leads to age-related behavioral and immunological changes in male rat offspring - the effect of antipsychotic drugs.
Journal Title: Pharmacological Reports - Year 2012, Vol 64, Issue 6
Abstract
Prenatal immune system disturbances have been postulated to play an important role in pathogenesis of schizophrenia and related disorders. In the present study, we sought to answer the question whether behavioral changes in the neurodevelopmental model of schizophrenia in rats are accompanied by alterations in proliferative activity of splenocytes and pro- and anti-inflammatory cytokine levels. Furthermore, the effects of two antipsychotic drugs on these parameters were determined.
Authors and Affiliations
Agnieszka Basta-Kaim, Ewa Szczęsny, Monika Leśkiewicz, Katarzyna Głombik, Joanna Slusarczyk, Bogusława Budziszewska, Magdalena Regulska, Marta Kubera, Wojciech Nowak, Krzysztof Wędzony, Władysław Lasoń
Keywords
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