Interleukin-10 and Interferon-γ Levels in Patients with Cutaneous Leishmaniasis Treated with Cryotherapy
Journal Title: Iranian Journal of Medical Sciences - Year 2017, Vol 42, Issue 5
Abstract
Pentavalent antimonials, as the 1st choice for the treatment of cutaneous leishmaniasis (CL), have various side effects. Also, there are some reports of drug resistance. Due to its safety, cryotherapy can be a good alternative or complementary treatment in CL. The aim of this study was to explore the possible systemic immunological mechanisms of cryotherapy besides its local effects in the treatment of CL. Twenty patients with CL were selected. The disease was confirmed via a direct smear. A venous blood sample was collected to determine IL-10 and IFN-γ levels before starting cryotherapy. Then, 1 week after 8 sessions of cryotherapy were completed (i.e., 63 d), a 2nd venous sample was taken in order to compare the results with the pretreatment levels of these cytokines using the ELISA method. Cryotherapy resulted in no change in the levels of IL-10 and significantly increased the IFN-γ levels in our patients with CL. Given these inconclusive or even mixed results, a larger sample size is needed in order to better assess the systemic immunological effects of cryotherapy.
Authors and Affiliations
Farhad Handjani, Saeed Reza Yousef, Nasrin Saki
Keywords
Related Articles
- EP ID EP247344
- DOI -
- Views 127
- Downloads 0
First Report on the Isolation of Nocardia Thailandica from the Bronchoalveolar Lavage sample of a Patient in Iran
With great interest, I read the first case report on the isolation of Nocardia thailandica from the bronchoalveolar lavage sample of an Iranian patient (IJMS volume September 2018).1 In light of the rarity of that opport...
Lymphangioma of the Thoracic Spine with Epidural Compression: A Case Report
Lymphangiomas are benign lesions consisting of abnormal proliferations of lymphatic vessels. Lymphangiomas associated with bone involvement, particularly in vertebral bodies, accompanied by cord compression, are extremel...
Effects of Essential Oil of SaturejaBachtiarica Bunge in a Rat Model of Reserpine-Induced Depression
Background: Due to the unfavorable side effects of some commonly used chemical drugs, the trend in the public has shifted towards using herbal medicines to treat central nervous system disorders like depression. The pres...
A Prospective Study of Altered Inflammatory Response and Its Clinical Outcome Following Laparoscopic and Open Cholecystectomy
Background: Inflammatory response following surgical trauma has long been a matter of study. Results, however, have been varied. We sought to assess changes in the levels of proinflammatory and anti-inflammatory cytokine...
Primordial Odontogenic Tumor of Mandible; A Case with Proposed Diagnostic Criteria
Primordial odontogenic tumor (POT) has been included as a new entity in a recent WHO (2017) classification of odontogenic tumors under benign mixed mesenchymal and epithelial tumors.1 Although there is controversy regard...