Interleukin-6 Levels in the Cervicovaginal Fluid of Pregnant Women and Its Predictive Value in Preterm Delivery
Journal Title: Bagcilar Medical Bulletin - Year 2020, Vol 5, Issue 3
Abstract
Objective: The aim of this study was to determine interleukin (IL)-6 levels in the cervicovaginal fluid of pregnant women and its value in predicting preterm delivery. Method: One hundred and eleven pregnant women were retrospectively included in the study. Cervicovaginal secretions for each pregnant woman were obtained with a sterile Dacron swab for IL-6 detection. IL-6 was determined using an enzyme-linked immunosorbent assay method. Results: The mean IL-6 levels were found to be significantly higher in the preterm delivery group (5.84±2.09 pg/mL) than in the term delivery group (2.24±0.77 pg/mL) (p=0.001). Relationships were found between IL-6 levels and the frequency of intra-amniotic infection, preterm birth and the history of previous preterm birth. Conclusion: A strong association was found between increased cervicovaginal fluid IL-6 levels and preterm delivery. Results suggest that measurement of IL-6 levels from cervicovaginal swab samples during pregnancy can be used to identify patients with risk as a predictive biomarker for preterm birth.
Authors and Affiliations
Pelin Ergenekon
Keywords
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- EP ID EP688682
- DOI 10.4274/BMB.galenos.2020.04.15
- Views 145
- Downloads 0
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