The Role of Granulocyte-macrophage Colony Stimulating Factor in Recurrent Pregnancy Losses
Journal Title: Bagcilar Medical Bulletin - Year 2019, Vol 4, Issue 3
Abstract
Objective: A specific factor cannot be detected in approximately half of recurrent pregnancy losses (RPL). The aim of the present study was to investigate the role of a cytokine, granulocyte-macrophage colony stimulating factor (GM-CSF), in the etiology of recurrent pregnancy losses. Method: A total of 50 patients who had been admitted to the gynecology and obstetrics clinics of İstanbul University Medical School between January 1995 and September 2001 were included into the study and allocated to five groups including control and study groups. The study groups included 30 patients and the control groups included 20 patients. There were 3 study groups including non-pregnant women who had abortion (2 groups) and a spontaneous abortion group, which were selected among the recurrent pregnancy loss (RPL) subjects with unknown etiology. The spontaneous abortion, non-pregnant RPL group and pregnant RPL group were accepted as study group). These groups were compared with the control groups, which included pregnant and non-pregnant healthy women. Results: Moderate and severe GM-CSF activity was detected in the decidua of all cases in fertile and elective termination groups. However no significant difference was detected in the surface epithelium, gland epithelium and stromal GCSF activities. Endometrial GM-CSF activity was determined to decrease in spontaneous abortion and RPL cases. Conclusion: Reduced GM-CSF activity in the decidua may have a role in the etiology of RPL. Besides, the level and distribution of GM-CSF in different compartments of the decidua may be a determinant factor in the prognosis of pregnancy.
Authors and Affiliations
Özlem Karabay Akgül, Emre Volkan Kasımoğulları, Hakan Güraslan, Cemil Akgül
Keywords
Related Articles
- EP ID EP50336
- DOI 10.4274/BMB.galenos.2019.07.011
- Views 221
- Downloads 0
Comparative Evaluation of the First-grade and Senior Medical School Students’ Knowledge and Attitudes Toward Thoracic Surgery
Objective: Comparison of the knowledge and attitudes of first and last year medical students about thoracic surgery. Method: The answers of the five questionnaires which were directed to the first and last year medicine...
Are Mean Platelet Volume and Neutrophil-to-Lymphocyte Ratio Related with Hepatosteatosis in Obese Children?
Objective: Obesity is an important health problem, which affects children and adolescents and is highly prevalent throughout the world. Non-alcoholic fatty liver disease is fattening that occurs due to non-alcohol causes...
A Rare Case: Malignant Granular Cell Tumor in Axillary Region
Granular cell tumors (GCT) are rare soft tissue tumors. Although it is frequently seen in the upper extremity, it can be seen anywhere in the human body. The majority of tumor cases are benign and approximately 2% are ma...
Palliation in Malignant Esophageal Stricture and Fistulas with Self-expandable Metallic Stents
Objective: We aimed to present the effectiveness of self-expandable metallic stents (SEMS) in dysphagia score and fistula closure, which are used in palliation for dysphagia and tracheoesophageal fistula seen in primary...
Evaluation of Readmitted Patients After Intensive Care Unit Discharge (Retrospective Study)
Objective: Nearly %10 of the discharged patients are readmitted to intensive care unit (ICU) at the same hospital stay. Reduction of readmission rates could be used as a hospital performance indicator. Our aim is to anal...