Interpretation of thyroid function tests
Journal Title: Journal of the Indian Medical Association - Year 2018, Vol 116, Issue 4
Abstract
Thyroid disorders are commonly encountered in clinical practice. Diagnosis and confirmation of thyroid disorders usually depends on accurate measurement and interpretation of thyroid function tests. The thyroid hormones (TH), T3 and T4 exert a negative feedback on TRH and TSH which helps maintain equilibrium. Modest changes in TH lead to major changes in TSH and hence TSH is often used as a screening test for thyroid hormone disorders. However, measurement of TH (Total T3 and T4 or Free T3 and T4) are often necessary for accurate interpretation and treatment of thyroid disorders. Raised T4 and T3 with suppressed TSH is suggestive of thyrotoxicosis and low T4 and T3 with elevated TSH is suggestive of hypothyroidism. Thyroid peroxidase antibodies and Thyroid stimulating hormone receptor autoantibodies (TRAbs) are useful for diagnosis of Hashimoto’s thyroiditis and Graves’ disease respectively. Serum Thyroglobulin is useful in follow-up of patients who are treated for thyroid cancer. Assay interference should be considered in cases where thyroid function test results do not correlate with the clinical status.
Authors and Affiliations
Altamash Shaikh, Om J Lakhani
Keywords
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