Interrelation of Argyrophilic Proteins of Nucleolar Organizer Regions and Ki-67 with Clinical and Morphological Parameters and Survival in Patients with Non-small Cell Lung Cancer
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 22
Abstract
Argyrophilic proteins associated with nucleolar organizer regions (AgNOR) and Ki-67 were studied at non-small cell lung cancer (NSCLC). Tumors with low and high area index (AI) of AgNOR and label index (LI) Ki-67 were defined. AI AgNOR was related to the key clinical and morphological parameters in accordance with TNM system: values Т, N, greatest tumor dimension up to 3 cm and more, disease stage, histogenesis, and tumor differentiation. LI Ki-67 is related to the greatest tumor dimension up to 3 cm and more, disease stage, and tumor differentiation. NSCLC patients survival is longer in low AI AgNOR or LI Ki-67 tumors versus high AI AgNOR or LI Ki-67 tumors. NSCLC patients survival is longer in low AI AgNOR and LI Ki-67, shorter in high AI AgNOR and LI Ki-67, and intermediate in opposite AI AgNOR and LI Ki-67. Value N, greatest tumor dimension, histogenesis, AgNOR are independent predictors in NSCLC. NSCLC patients survival without metastases to lymph nodes is related to the greatest tumor dimension and in case of metastases it is related to AI AgNOR and greatest tumor dimension. Combined determination of AgNOR and Ki-67 has prognostic value at NSCLC.
Authors and Affiliations
D. S. Kobyakov, E. Yu. Bychkova, A. M. Avdalyan, I. P. Bobrov, A. F. Lazarev, N. M. Kruglova, E. L. Lushnikova, L. M. Nepomnyaschikh
Keywords
Related Articles
- EP ID EP349295
- DOI 10.9734/BJMMR/2014/10319
- Views 53
- Downloads 0
Peculiarities of Cognitive Disorders in Adult Patients with Epilepsy
Aim: The basic aim of the article is to study the state of cognitive functions in patients with epilepsy due to clinical characteristics and a pharmacological group of received anticonvulsive medicines using MMSE test an...
Erupting Odontome- A Compilation of Two Rare Case Reports
Odontomas are the most common type of benign odontogenic tumours; they are asymptomatic and are often discovered during routine radiographs of the jaws. Odontomes can be used as stem cell reservoirs and generally eruptio...
Microleakage of Two Cementing Agents Using Different Application Techniques
The coronal leakage of bacteria and other irritants to the radicular canal system is one of the main factors that may result in clinical failure and affect the long term success of adhesive cementation and endodontic tre...
Effect of Cytomegalovirus and Diabetes Mellitus on the Cytokine Profile of Cellular Immunity in Tuberculosis Patients
Aims: This study aims to investigate the effect of cytomegalovirus (CMV) and diabetes mellitus (DM) on the cell-mediated immunity against TB represented by cytokine profile Study Design: Case control study. Place and D...
Pseudo-hypoparathyroidism Coexistent with Systemic Sclerosis: A Rare Case Report
Background: Systemic sclerosis is a chronic autoimmune inflammatory disease with wide-spread fibrosis of the skin and internal organs. The hypoparathyroidism associated with systemic sclerosis is infrequent and rarely re...