Intra-lesional Cidofovir injection to treat Recurrent Respiratory Papillomatosis: Review of literature.
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2017, Vol 7, Issue 1
Abstract
ABSTRACT:- Introduction: Recurrent respiratory papillomatosis(RRP) is a disease of the upper aerodigestive tract caused by infection with human papilloma virus(HPV) 6/11/16/18. Treatment involves surgical removal of the epithelial lesion in order to maintain airway patency and phonation. Objective: Review of literature to analyse the effect and safety of intra-lesional Cidofovir injection in patients with RRP. Method: Literature search done via Pubmed and NHS Athens using key words Cidofovir and RRP. Out of sixty two, thirty three articles studied consist of literature reviews and case series, systemic use and adverse effects of Cidofovir. Result: The relapse-free duration increases and RRP gets less aggressive with intra-lesional Cidofovir which is a cytosine nucleoside analogue antiviral medication. Incidence of dysplasia or malignant degeneration which can occur with Cidofovir is the same as spontaneous malignant degeneration of RRP(2-3%). Conclusion: Intra-lesional Cidofovir controls aggressive lesions of RRP without increasing the risk of laryngeal dysplasia. For evaluation of safety; further research is required to define adequate dose and frequency of treatment. Histology of the lesions at every procedure and assessment of HPV genotype would help to monitor response to treatment, detect dysplasia and progress of the disease.
Authors and Affiliations
Ms. Rupali Sawant
Keywords
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