Effects of D-002 on Formaldehyde-Induced Osteoarthritis in Rats
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2013, Vol 3, Issue 7
Abstract
ABSTRACT: BACKGROUND: The treatment of Osteoarthritis (OA) is addressed to pain alleviation and functional status improvement. Non-steroidal anti-inflammatory drug (NSAIDs), widely prescribed for OA, have been show to produce gastrointestinal (non selective) and cardiovascular (ciclooxygenase– 2 inhibitors) adverse effects. Then, the search for new substances is justified. D-002 is a mixture of higher aliphatic beeswax alcohols withanti-inflammatory and gastroprotective, rather than gastrotoxic effects. OBJECTIVE: To investigate the effects of D-002 on formaldehyde-induced OA in rats. METHODS: OA was induced by formaldehyde injection. Animals were orally dosed with either D-002 (50, 200 and 400 mg/kg) or naproxen (NAP) (3 mg/kg), as reference drug. Controls comprised negative and vehicletreated rats. Treatments were administered for 10 days. The effects were assessed by measuring the changes on the diameters of rat ankle and paw.RESULTS: The formaldehyde injection significantly increased the diameters of rat paw and ankle as compared to the negative control group, changes that were significantly decreased by naproxen. All doses of D-002 significantly reduced these increases as compared to the positive control, but not dose-dependently. The effects of the lowest and highest doses were practically the same. The effect of the highest dose of D-002 was significantly lower than that of NAP.CONCLUSIONS: Oral administration of D-002 (50 – 400 mg/kg) significantly decreased the formaldehydeinduced increases of rat paw and ankle enlargement, albeit less effectively than NAP. These results encourage to investigate its effects on other experimental models of OA.
Authors and Affiliations
Sarahi Mendoza, Maikel Valle,
Keywords
Related Articles
- EP ID EP125808
- DOI -
- Views 81
- Downloads 0
Formulation and Evaluation of Taste Masked Fast Disintegrating Tablet of Promethazine Hydrochloride
Methods: Taste masking of Promethazine Hydrochloride was achieved by microencapsulation using amino alkyl methacrylate copolymers (Eudragit E100) employing the solvent evaporation technique. Taste assessment was carried...
Evaluation Of Adverse Effects Of Antituberculosis In El-Idrissi Hospital, Kenitra, Morocco
The main obejective of the study is to evaluate the adverse effects of antituberculosis. The present prospective study was conducted from the 2ndof April of year 2012 to the 2ndof April of 2013 with the help o...
[b] Interaction Between Cibacron Blue F3GA and Luteinizing Hormone: A Chromatographic Investigation[/b]
A Review On The Diverse Application Of Silver Nanoparticle
Abstract:-Nanotechnology is an emerging field with diverse applications in pharmacy, medicine, industries and environments. Among nanosized particles, the inorganic nanoparticles posses unique physical and chemical prope...
Pharmacognostical and Phytochemical Studies of KukutnakhiAspidium Cicutarium - A Folklore Plant
Aspidium cicutarium L. from Dryopteridaceae family is a folk medicinal plant used in the treatment of shotha (inflammation). The rhizomes of this herb are said to be successful in managing Inflammation....