INTRA SPERMIC CALCIUM STORE IN REVERSIBLE STATE OF CALCIUM RIGOR IS RESPONSIBLE FOR SPERM MOTILITY AND POLYSPERMY PREVENTION – A NEW PERSPECTIVE
Journal Title: International Journal of Basic and Applied Physiology - Year 2016, Vol 5, Issue 1
Abstract
Non-pulsatile GnRH during spermatogenesis is responsible for production of less Estrogen [OE] and Progesterone[PR] with more Androgens in male. With relative lack of PR [respiratory alkalosis] induced Ca2+ lowering mechanism, Ca2+ bioavailability is enhanced in male. Ca2+ triggered centriolar spindle contraction favouring mitotic and meiotic divisions of spermatocytes produce millions of haploid spermatids daily and stockpile them in reversible Ca2+ rigor state in anaerobic acidic environment of male genital tract. Thusintraspermic Ca2+ store is formed. On ejaculation aerobic environment favours spermic mitochondrial ATP production causing Ca2+ etachment from its’ binding site, maintains continuous supply of active IntraSpermic Ca2+. Resultant continuous Spermic Ca2+ efflux triggers semen coagulation, coagulum liquefaction by acrosomal proteolytic enzymes action and restores sperm motility with cyclical binding and releasing of Ca2+ from flagellar contractile proteins. Motile sperm penetrate corona radiata of secondary oocyte by proteolytic acrosomal enzyme action and bind to species specific Zona Pellucida [ZP] receptor. On entry, sperm loses membrane releasing active Ca2+ intra-oocytically. Resultant Ca2+ wave/spark triggers centriolar contraction forming second polar body cause progress in arrested 2nd meiosis of secondary oocyte. Ca2+ wave/spark is responsible for fast electrical block and triggers slow block by Ca2+ salts deposition at oolemma, prevent further sperm entry
Authors and Affiliations
Asha Anand Dharwadkar, Anand Rajendra Dharwadkar, Bindu Balakrishnan Chenmarathy
Keywords
Related Articles
- EP ID EP534814
- DOI -
- Views 59
- Downloads 0
RELATIVE MERITS OF DIFFERENT CLEARANCE TESTS USED TO MEASURE GFR
Merits and demerits of various renal clearance tests that are used to measure GFR are compared and it appears that the measurement of creatinine clearance tests is the best one and when GFR is less than 60 ml/min simply...
LUTEAL PHASE SERUM CALCIUM AND SERUM MAGNESIUM LEVELS IN CAUSATION OF PREMENSTRUAL SYNDROME
Background: Premenstrual syndrome involves a variety of physical, mental and behavioural symptoms tied to a woman’s menstrual cycle. It is a complex health problem and is currently defined as the cyclical occurrence of n...
EFFECT OF SUDARSHAN KRIYA YOGA ON CARDIAC, AUTONOMIC AND PULMONARY FUNCTIONS
Introduction: Yogic breathing techniques are often recommended for relaxation and stress management. This has been claimed to have effect over autonomic nervous system imbalances and psychological or stress-related disor...
A CROSS SECTIONAL STUDY OF ASSOCIATION BETWEEN SELECTED HAND ANTHROPOMETRIC VARIABLES AND HANDGRIP STRENGTH IN YOUNG ADULTS: A GENDER DIFFERENCE APPROACH
Background and objectives: Isometric hand grip strength as assessed by Maximum Voluntary Contraction (MVC) is a measure of athletic talent and morbidity outcomes. The present study investigated the possible association o...
EVALUATION OF MULTIFOCAL ERG AND A-SCAN BIOMETRY IN MYOPIC EYES.
Background: Myopia is a common type of refractive error. It is a non-life-threatening disorder with huge social and economic consequences due to its increasing prevalence. Axial length (AL) is the primary determinant of...