Intrathecal Bupivacaine with Different Doses of Clonidine in Elective Surgeries: A Comparative Study
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 10
Abstract
Intrathecal clonidine is a very safe, nonopioid adjuvant to local anesthetics to prolong the duration of analgesia without any major side effects. The purpose of the present study was to evaluate the efficacy of clonidine in two different doses as an adjuvant to bupivacaine intrathecally in elective surgeries. This study include 80 patients aged between 20-60 years of both sexes divided in two two groups each consist of 40 patients. Group A received hyperbaric bupivacaine (2.5 ml) +50 μg clonidine (diluted to 0.5 ml) administered intrathecally and Group B– Received hyperbaric bupivacaine (2.5 ml) +75 μg clonidine (diluted to 0.5 ml) administered intrathecally. The mean time of onset of sensory block and motor block were comparable between two groups, but Duration of sensory block and motor block were significantly increased as the dose of clonidine increased and recue analgesia also decreased. Maximum fall in systolic blood pressure during first 15 min was noticed. There was no significant difference in the mean values of heart rate at different time intervals between the two groups. There was no significant difference in systolic blood pressure, diatolic blood pressure and mean arterial blood pressure in two groups. Sedation score were increased as the dose of clonidine is increased. Hence it is concluded that addition of intrathecal clonidine 50-75μg to small dose bupivacaine increased the spread, duration of analgesia, and produced effective spinal anesthesia with stable hemodynamics.
Authors and Affiliations
Dr. Uppalapati Swathi, Dr. Irukulla Avanthi, Dr. S. Manohar
Keywords
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