Intrathecal Clonidine as an Adjuvant to Hyperbaric Bupivacaine: A Dose - Response Study
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 1
Abstract
Introduction: Clonidine, an α2 agonist, prolongs the action of local anaesthetic and provides satisfactory postoperative analgesia when administered intrathecally. Study aimed to compare the effects between two doses of clonidine (30 and 60 μg) in terms of hemodynamic profile, duration of analgesia, sensory and motor blockade, when used intrathecally as an adjuvant to 2.5 ml of 0.5% hyperbaric bupivacaine. Material and Methods: In this prospective, randomised, double blind study, 80 patients of American Society of Anaesthesiologists (ASA) I or II, aged 18 – 55 years, undergoing lower abdominal or lower limb surgery lasting less than 180 minutes were included. Patients were divided into two groups of forty patients each and they received intrathecally, 2.5 ml of 0.5% hyperbaric bupivacaine and either 30 μg of clonidine (Group C30) or 60 μg of clonidine (Group C60). Total volume was made constant by adding normal saline. Haemodynamic parameters, duration of sensory and motor blockade and duration of analgesia were noted. A p value <0.05 was considered significant. Results: Both groups were comparable with respect to demographic profile and haemodynamic parameters. Duration of sensory block, motor block and analgesia were significantly prolonged in Group C60 as compared to Group C30. Conclusion: Addition of clonidine to hyperbaric bupivacaine increased the duration of spinal anaesthesia and post operative analgesia in a dose dependent manner with minimal adverse effects.
Authors and Affiliations
Sara Mary Thomas, Mary Verghese, Melchisedec .
Keywords
Related Articles
- EP ID EP428889
- DOI -
- Views 95
- Downloads 0
Assessment of Risk of Development of Hypertension among Obese People: A Retrospective Study
Introduction: One of the risk factors which is hypothesized to increase the risk of development of hypertension is obesity. Among Asian population, several studies have shown that obesity is one of the risk factors for d...
Comparative Study of Oral Premedication in Children with Ketamine and Midazolam
Introduction: Pre-operative anxiety (anxiety regarding impending surgical experience) in children is a common phenomenon that has been associated with a number of negative behaviors during the surgical experience (e.g. a...
Comparison of Upper Airway Ultrasonography with Standard Waveform Capnography and Auscultation to Verify Correct Placement of Endotracheal Tube after Intubation
Introduction: Verification of correct endotracheal tube (ETT) placement and avoidance of esophageal, endobrocheal intubation has important implications. Ultrasonography (USG) is an indispensible method in ETT position co...
Sunscreen Awareness in Medical Undergraduates
Introduction: Many international studies have been conducted to assess the knowledge, attitude and practices of the public towards sun exposure and sun-protection measures but very few such studies have been conducted in...
Urogenital Infections – A Cause of Pre Term Labor
Introduction: Urogenital infections (UGIs) are mostly widespread when unhygienic condition and during pregnancy and considered as as an important cause of premature labor. Preterm labour is the one of the foremost reason...