Intrathecal dexmedetomidine’s effect on the requirement of dose of hyperbaric bupivacaine in spinal anesthesia in the caesarean section patients
Journal Title: International Journal Of Research In Medicine - Year 2019, Vol 8, Issue 1
Abstract
BACKGROUND AND OBJECTIVES: Regional anaesthesia has become more popular in caesarean deliveries because most of the parturients prefer being awake during child birth. In addition it is a safer method than general anaesthesia. Present study was done with an aim to determine the ED95 of intrathecal hyperbaric bupivacaine with or without Dex as an adjuvant in spinal anaesthesia for caesarean section using an improved up-down sequential allocation method. METHODS: : A total of 90 participants were included in the study. All the participants were of physical class I or II. All the participants were enrolled for elective caesarean section.They were equally divided into two groups. The study solution for the two groups was 0.75% hyperbaric bupivacaine mixed with 5 mcg of Dex (Dex Group ) or saline (Control Group) and was diluted to 3 mL with saline. A volume not greater than 1 mL was extracted using an insulin syringe (1 ml).The primary outcome of this study was successful anaesthesia or unsuccessful anaesthesia. The secondary outcomes of this study were the characteristics of spinal anaesthesia, analgesic duration of spinal anaesthesia and side-effects.RESULTS There was a significant difference in the duration of the sensory block between the Dex group and the Control group.The total requirement of postoperative rescued sufentanil during the first 24 h in the Dex group was less than in the Control. There was no significant difference in the patient satisfaction of analgesia between the two groups (P>0.05). CONCLUSION: Intrathecal 5 mcg dexmedetomidine potentiated hyperbaric bupivacaine antinociception by 31% in spinal anaesthesia for patients undergoing caesarean section and prolonged the spinal analgesia duration without additional side effects.
Authors and Affiliations
Poonam M Vaghela Arpit J Gohel
Keywords
Related Articles
- EP ID EP553305
- DOI -
- Views 103
- Downloads 0
A Study on Clinical Profile & Prognostic Indicators in Patients with Acute Poisoning
BACKGROUND: Organophosphoruspoisoning is associated with significant morbidity and mortality in developing countries. This study was done to study common clinical profile & predictors for poor prognosis in these patients...
A Study on Hemodynamic Parameters Stability by Rocuronium Bromide during Anaesthesia for Elective Surgical Procedures in a Tertiary Care Hospital
BACKGROUND AND OBJECTIVES: Hemodynamic stability is an important aspect of anaesthesia care. Anaesthesia has tendency to produce significant hemodynamic changes especially during induction and intubation. Intravenous Roc...
A Prospective Randomised Study of Comparing Diathermy and Ultrasonic Scalpel Haemorrhoidectomy
BACKGROUND: Haemorrhoidectomy is the most effective approach for haemorrhoidal disease especially for grade III and grade IV disease. However, postoperative pain is a major concern, and the surgery itself is with complic...
Efficacy of octreotide in postoperative alimentary tract fistulas
BACKGROUND: With the passage of time, there has been changing pattern of incidence and mortality of enterocutaneous fistulae. The earliest record of enterocutaneous fistulae appears in the “The old testament of judge...
Clinical profile of patients with extra pulmonary tuberculosis in Gujarat
BACKGROUND: In spite of knowledge and means for the diagnosis and treatment of disease, Tuberculosis (TB) continues to remain a major public health problem in developing countries. It is comparatively easy to diag...