Intrathecal Nalbuphine as an Adjuvant to Spinal Anaesthesia: What is Most Optimum Dose?
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 1
Abstract
Background: To find out the most effective dose of nalbuphine as an adjuvant to spinal anesthesia. To compare the three different doses and find out most optimum dose of nalbuphine with minimal side effects and maximum analgesic effect. Materials and Methods: We conducted prospective randomized double-blinded controlled study with 120 American Society of Anesthesiology I and II patients who were undergoing lower limb orthopedic surgery under spinal anesthesia. We randomly allocated four Groups A, B, and C to receive 0.4, 0.6, and 0.8 mg nalbuphine made up to 0.5 ml with distilled water, and Group D receive 0.5 ml of plain distilled water added to 2.5 ml of 0.5% hyperbaric bupivacaine (3 ml), respectively. The onset of sensory block and motor block, duration of surgery, duration of motor blockade and analgesia, visual analog scale score, vital parameters, and adverse effects compared between these groups. Findings: No difference was noted in the onset of sensory and motor blockade among the four groups. Duration of two-segment regression time of sensory block, duration of motor blockade, and duration of analgesia time were prolonged in Groups B (0.6 mg) and C (0.8 mg) and found to be significant. The incidence of adverse effects was frequently higher in Group C (P < 0.005) compared to other groups. Conclusion: Nalbuphine is effective adjuvant in spinal anesthesia, in a dose of 0.6 mg to prolong the duration of analgesia without increased adverse effects.
Authors and Affiliations
S Kumaresan, A Anbu Muruga Raj
Keywords
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