Intravenous drug incompatibility in intensive care units - A comprehensive review
Journal Title: Innovations in Pharmaceuticals and Pharmacotherapy (IPP) - Year 2018, Vol 6, Issue 3
Abstract
In intensive care unit, intravenous (IV) therapy is preferred over oral therapy for a faster therapeutic action. IV therapy is complex and error prone, requiring strategies to reduce the risk and complications. Once injected, reversing the action is not possible unless an antidote exists. Drug incompatibility results from the simultaneous dilution and/or administration of two or more drugs that interfere with the therapeutic efficacy of the medications and patient safety, visually evidenced by the change of solution color, precipitation, or turbidity. Incompatibility occurs in vitro, which differentiates it from real drug interactions that occur in vivo. Medication errors such as wrong drug, dose, diluents, and cross-contamination errors with IV therapy further lead to death and harm to the patient. This is a narrative review of physical and chemical IV drug incompatibilities and explores the preventive strategies for the same. Findings from this review are useful in addressing current practice challenges
Authors and Affiliations
S. Sriram
Keywords
Related Articles
- EP ID EP570082
- DOI -
- Views 89
- Downloads 0
Impact of antiviral therapy on quality of life in hepatitis C patients measured using short form-36 questionnaire: A prospective observational study
Aim: Even in the absence of cirrhosis, health-related quality of life (HRQOL) of hepatitis C virus (HCV) infected patients is low compared to healthy adults. HCV replication leads to various hepatic and extrahepatic mani...
Evaluation of in vitro and in vivo antimalarial activity of Hymenodictyon excelsum bark extracts
The present study was designed to evaluate in vitro and in vivo antimalarial activity of different extracts of Hymenodictyon excelsum bark which is used in the treatment of malarial fever as a febrifuge. The preliminary...
Design and evaluation of floating gastro retentive tablets of fixed dose combination of ciprofloxacin and metronidazole
Gastro-retentive drug delivery systems offer the advantage in prolonging the gastric emptying time for drugs having a narrow absorption window in the gastrointestinal tract (GIT) resulting in poor absorption. Ciprofloxac...
Transdermal drug delivery by iontophoresis: Mechanistic aspects
The passive diffusion of drugs in transdermal delivery is hindered by the stratum corneum and limits the scope of deliverable molecules through the skin. The evolution of novel electrical and physical enhancement techniq...
Formulation and evaluation of sustained release glipizide tablet using different polymers
The glipizide sustained release (SR) tablet was prepared using different hydrophilic polymers such as hydroxypropyl methylcellulose (HPMC) K4M, HPMC K100M, and ethyl cellulose in various proportions. Design Expert softwa...