Evaluation of in vitro and in vivo antimalarial activity of Hymenodictyon excelsum bark extracts
Journal Title: Innovations in Pharmaceuticals and Pharmacotherapy (IPP) - Year 2015, Vol 3, Issue 1
Abstract
The present study was designed to evaluate in vitro and in vivo antimalarial activity of different extracts of Hymenodictyon excelsum bark which is used in the treatment of malarial fever as a febrifuge. The preliminary phytochemical screening of different extracts of Hymenodictyon excelsum bark showed the presence of alkaloids, flavonoids, glycosides, steroids, tannins and terpenoids. The ethyl acetate extract of Hymenodictyon excelsum has shown dose dependent percentage Inhibition of schizont maturation of Plasmodium falciparum and the highest in vitro antimalarial activity by schizont maturation inhibition assay indicated by IC50 = 35.72 µg/ml. Percentage parasitaemia with 50, 100 and 200 mg/kg/day doses of ethyl acetate extract of Hymenodictyon excelsum ranged from 8.33 ± 0.29 to 6.33 ± 0.29 and maximum percentage chemosuppression was observed with 200 mg/kg/day dose which was highly significant (86.63 %) as compared to standard (85.93%). The maximum survival of mice was observed with 200 mg/kg/day of ethyl acetate extract of Hymenodictyon excelsum (28 days) whereas, less significant results were recorded with petroleum ether extract (12.00 ± 1.00 days). Thus, it can be concluded that the ethyl acetate extract of Hymenodictyon excelsum could be possessed antimalerial activity.
Authors and Affiliations
P. B. Suruse
Keywords
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