A comprehensive review on antipsychotics in dentistry
Journal Title: Innovations in Pharmaceuticals and Pharmacotherapy (IPP) - Year 2015, Vol 3, Issue 2
Abstract
Psychiatric disorders are not uncommon; almost 10% of the population worldwide is affected. They are characterized by disorganized thought process, bizarre behavior and emotional reactions, these individuals may experience delirium, hallucinations, confusion and may interpret the surrounding events differently. Overall prevalence rate of psychic disorders in India vary from 9.5 to 370 per 1000 population. A variety of psychotropic drugs combined with psychotherapy, cognitive behavioral therapy and family support help to cope with this illness. Antipsychotics are categorized as first generation (conventional or typical) and second (atypical) generation antipsychotics. Though they are safe and have high therapeutic index, they all come with wide ranging side effects i.e. sedation, postural hypotension, extrapyramidal signs (dystonia, tardive dyskinesia), disturbed metabolism, agranulocytosis, thrombocytopenia, dyslipidemia and prolactin levels. They also lead to oral manifestations such as dry mouth, increase in cavities, sialorrhea, taste abnormalities (dysgeusia, ageusia). The drugs which are routinely prescribed by an oral physician such as NSAIDs, erythromycin and tramadol may possibly interact with antipsychotics reducing their efficacies. Over the last few decades there has been a tremendous increase in the use of antipsychotics; consequently negative impact on oral health has been increasing. Tact and skill in diagnosis of mental illnesses/use of antipsychotics is essential due to social stigma associated with these disorders. Prejudicial attitude in health care workers is another hindrance which must be overcome. Hence dental health care worker should have an assiduous approach while dealing with these patients so as to reduce morbidity or life threatening circumstances.
Authors and Affiliations
Pearl Helena Chand
Keywords
Related Articles
- EP ID EP569126
- DOI -
- Views 73
- Downloads 0
Synthesis, characterization and biological evaluation some novel schiff base and mannich base of isatin and its derivatives with benzimidazole
Isatin is a synthetically versatile substrate, where it can be used for the synthesis of a large variety of heterocyclic compounds and as a raw material for drug synthesis. In the past few decades, Isatin and its derivat...
Evaluation of vitamin B12 deficiency in preschool children-A pilot study in east Delhi
Anemia is an important health concern worldwide, particularly in tropical and sub-tropical countries such as in India. The objective of the present study was to determine the prevalence of vitamin B12 deficiency in pre-s...
In vitro comparative studies of antioxidant action of different parts of sweet and bitter variety of Lagenaria siceraria
Objective: The object of the present investigation is to verify the antioxidant activity of sweet and bitter variety of Lagenaria siceraria (LS) and to investigate the medicinal properties of whole plants. Materials: Asc...
Phophodiesterase-4 enzyme inhibitors as potential anti-inflammatory agents
The Phosphodiesterases (PDEs) are a diverse family of enzymes that hydrolyze cyclic nucleotides such as cAMP & cGMP to the inactive 5’-AMP and 5’-GMP, respectively and thus play a key role in regulating intracellular lev...
Antibiotic sensitivity pattern of bacterial isolates in burns wound infection in a tertiary care hospital
Infection is an important cause of mortality in burns. Rapidly emerging nosocomial pathogens and the problem of multidrug resistance necessitates periodic review of isolation patterns and antibiogram in the burns ward. A...