Intravenous Injection of Autologous Bone Marrow Derived Mononuclear Cells in Ischemic Stroke Patients in Iraq
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2017, Vol 1, Issue 1
Abstract
Stroke is a leading cause of adult disability worldwide and the second highest cause of death in the world. Mortality rate is about 20% and another third are left with permanent disability. Treatments for stroke are based on methods that restore the flow of blood to the brain, such as clot-busting enzymes, surgery, and drugs for thinning blood, stopping clots and protecting neurons. Scientists believe that mesenchymal stem cell protection may be due to secretion of growth factors that promote growth of new neurons, regulate the immune system and stimulate the formation of new blood vessel, Or due to neurogenesis. Autologous bone marrow derived mononuclear cells with closed method is very near to minimal manipulation and low risk procedure. In this study, we aspirated 100 cc (mean volume) of bone marrow from 50 Iraqi adult patients (age ranges 34-86 years) (12 females 38 male) after filtration we injected 40 cc volume intravenously, mononuclear cell count was =5-6x10 7per product. The time from diagnosis till procedure performance was (3months-5 years), The effect of intravenous administration of autologous bone marrow mononuclear cells (BMMNCs) lead to improvement in European scale for stroke (+4-20) in 28 patients out of 50 (56%) in 4-8 weeks ). This study shows the positive effect of autologous bone marrow derived mononuclear cells in the functional recovery of adult patients with chronic ischemic stroke. Stroke is a leading cause of adult disability worldwide and the second highest cause of death in the world. Mortality rate is about 20% and another third are left with permanent disability. The majority of strokes (85%) are ischemic, while 15% is hemorrhagic due to a rupture of a brain artery causes bleeding into the brain tissue. Risk factors for stroke include high blood pressure, irregular heartbeat, diabetes, smoking, carotid artery narrowing, high blood cholesterol, increasing age, and lifestyle factors (exercise, diet and alcohol). Preventive measures include a diet low in fat and sodium, controlling blood pressure and alcohol intake, maintaining healthy weight, and regular exercise. Treatments for stroke are based on methods that restore the flow of blood to the brain, such as clotbusting enzymes, surgery, and drugs for thinning blood, stopping clots and protecting neurons [1,2]. Local Stem cells might be activated or transplanted from the same patient or another healthy one or from embryonic or cord blood sources [3]. There are many sources of stem cells used clinically to treat ischemic stroke including autologous bone marrow derived or adipose derived stem cells or cultured mesenchymal cells, neural cells derived from embryo, or cord blood cells induced pluripotent stem cells, and Wharton jelly mesenchymal cells. The trials underway are providing preliminary proof of the safety and potential effectiveness of the treatment, but there is still a long way to go before they show significant clinical changes for patients [4]. Safety issues, cell tracking and effectiveness are very vital issues in validating stem cell translational therapy [5].
Authors and Affiliations
Abdul Majeed Alwan Hammadi, Fizel Abbas Al-himyari
Keywords
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- EP ID EP566663
- DOI 10.26717/BJSTR.2017.01.000113
- Views 172
- Downloads 0
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