Intravenous iron supplementation for correcting renal anemia in hemodialysis patients – critical approach to current practices based on single-centre experience
Journal Title: Postępy Nauk Medycznych - Year 2011, Vol 24, Issue 4
Abstract
Intravenous iron, the procedure of choice to replete iron stores in hemodialysis patients can induce oxidative stress if the amount of “free” iron infused exceeds the capability of transferrin to bind it. TSAT increases significantly after both, iron saccharate and LMW-dextran I a dose-dependent manner. The retrospective study was undertaken to evaluate the maximum safe doses of both iv iron formulations and to design a protocol for iron repletion with minimum risko of “oversaturating” plasma transferrin. The 100 mg of LMW iron dextran proved safe in this regard in all patients, but the maximal safe doses in severe iron depletetion were 50 mg and 200 mg for iron saccharate and LMW iron dextran 200 mg , respectively. Based on the observations a protocol for single dose iron amount and dose-interval was proposed. The literature review to support the rationale to avoid transferrin oversaturation with intravenous iron was also presented.
Authors and Affiliations
Ryszard Gellert, Tomasz Żelek, Dorota Daniewska, Anna Kajczuk-Kowieska, Danuta Kobus
Keywords
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