Intravenous promethazine vs. diazepam to reduce symptoms of peripheral vertigo in emergency section: a double blind clinical trial
Journal Title: Eurasian Chemical Communications - Year 2019, Vol 1, Issue 0
Abstract
The present research aimed to compare the effectiveness of promethazine and diazepam in patients suffering from acute peripheral vertigo. This is a double blind clinical trial with a sample of 154 patients visiting the emergency section of Shahid Mohammadi Hospital in Bandar Abbas in 2017-18. The participants were randomly divided into two groups of 77, one treated with intravenous promethazine (50 mg) and the other with intravenous Diazepam (10 mg). The severity of vertigo was measured qualitatively and quantitatively 20 minutes later in both groups. Participants were 46 (29.9%) male and 108 (70.1%) female visiting the emergency section of hospital. The mean score of vertigo severity in Promethazine group was 44.44±17.94 and that of Diazepam group was 2.49±+3.87. The severity scores before and after the treatment in promethazine group were respectively 7.75±1.59 and 2.72±1.93. The mean scores of vertigo severity before and after the treatment in promethazine group was -5.04+2.10 and in the diazepam group it was -3.83+3.09. The intergroup difference was statistically significant (p=.013). The results revealed that intravenous promethazine and diazepam applied 20 minutes after prescription are both effective in controlling the severity of vertigo. Considering the probability of occurrence of extrapyramidal side-effects it can be suggested that the infusion of this medication be done slowly and take longer time. Meanwhile, vital signs should be precisely controlled.
Authors and Affiliations
Saeed Hayati, Reza Yazdani, Soghra Fallahi, Zivar Atashbar, Seyed Ashkan Tabibzadeh Dezfuli
Keywords
Related Articles
- EP ID EP658133
- DOI 10.33945/SAMI/ECC.2019.6.4
- Views 142
- Downloads 0
QSAR models to predict physico-chemical Properties of some barbiturate derivatives using molecular descriptors and genetic algorithm- multiple linear regressions
In this study the relationship between choosing appropriate descriptors by genetic algorithm to the Polarizability (POL), Molar Refractivity (MR) and Octanol/water Partition Coefficient (LogP) of barbiturates is studied....
A computational molecular approach on chitosan vehicle for metformin
Density functional theory (DFT) calculations have been performed to study properties of chitosan (Chit) as a possible vehicle for carrying metformin (Met) drug. To this aim, the singular molecules of Met and Chit have be...
Physico-chemical evaluation of a biocompatible microemulsion system containing IPM/Tween80/Isobutanol
A biocompatible microemulsion system comprising of isopropyl myristate (IPM) as oil, tween 80 as a non-ionic surfactant and isobuthanol as co-surfactant was studied experimentally at 298.15 K. The pseudo-ternary phase di...
The Synthesis of silver nanoparticles using Beetroot extract and its antibacterial and catalytic activity
Silver nanoparticles (NPs) have been synthesized by aqueous Beetroot extract. Effective parameters on the synthesis of silver NPs like pH, extract volume, silver nitrate concentration and time of reaction have been inves...
Green synthesis and characterization of silver nanoparticles using Scrophularia Striata extract
Here, green synthesis of silver nanoparticles (NPs) using aqueous extract of Scrophularia Striata was demonstrated. In order to obtain the best formation conditions of NPs, different physicochemical parameters such as vo...