Introduction of Zika virus in Bangladesh: An impending public health threat
Journal Title: Asian Pacific Journal of Tropical Medicine - Year 2017, Vol 10, Issue 9
Abstract
Objective: To explore the presence of Zika virus (ZIKV) in Bangladesh and to understand the associated risk factors. Methods: A retrospective sero-surveillance was performed on stored serum samples of dengue surveillance conducted from 2013 to 2016. Real time RT-PCR was performed on randomly selected acute serum samples to detect the Zika virus nucleic acid. Results: Of 200 samples screened, one was found positive for ZIKV by real time RTPCR and further confirmed by genome sequencing. The case was a 65 years old male from a metropolitan city of Bangladesh who had no history of travel outside Bangladesh. Phylogenetic analysis of partial E gene sequences from Bangladeshi isolates demonstrated a close relationship with ZIKV from Brazil and current South American strains clustering within a monophyletic clade distinct from African lineage. Conclusions: Presence of ZIKV raises serious public health concerns in Bangladesh owing to its association with congenital anomalies/neurological-manifestations. We, therefore, recommend every suspected viral fever patient, particularly pregnant women be screened for ZIKV infection to rule out yet another emerging infection in Bangladesh.
Authors and Affiliations
Tahmina Shirin
Keywords
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- DOI 10.1016/j.apjtm.2017.08.015
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