INTUBATING CONDITIONS FOLLOWING RAPID SEQUENCE INDUCTION WITH THREE DOSES OF SUCCINYLCHOLINE
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 29
Abstract
BACKGROUND Whenever rapid sequence induction is considered, succinylcholine is the neuromuscular blocking agent used because of its rapid onset and recovery time. In this study, we are studying the minimum dose required for this purpose. This study consists of prospective, randomised, double-blind study to compare endotracheal intubating conditions and the apnoea duration after administration of 0.4, 0.6 and 0.8 mg/kg of succinylcholine in cases of rapid sequence induction of anaesthesia. MATERIALS AND METHODS Patients were randomly selected to 3 groups according to the dose of succinylcholine (0.4, 0.6 or 0.8 mg/kg). Anaesthesia was induced with fentanyl 2 μg/kg and propofol 2 mg/kg followed by application of cricoid pressure. Patients were intubated. Intubating conditions were assessed after 60 s of succinylcholine administration. Time of first diaphragmatic contraction (apnoea time) and time for resumption of regular spontaneous breathing were noted. RESULTS Intubating conditions were excellent for 0.4, 0.6 and 0.8 mg/kg succinylcholine; they were 52.4%, 95.7% and 100% respectively; P < 0.001. Acceptable intubating conditions (excellent and good grade combined) for 0.4, 0.6 and 0.8 mg/kg succinylcholine were 66.7%, 100% and 100% respectively; P < 0.001. Apnoea time for groups 0.4, 0.6 and 0.8 mg/kg was 3.8 ± 1.1 min, 4.3 ± 0.9 min and 8.2±3.4 min respectively; P < 0.001. Time for regular spontaneous breathing for groups 0.4, 0.6 and 0.8 mg/kg were 5.3 ± 1.2 min, 5.5±1.1 min and 8.9 ± 3.5 min respectively; P < 0.001. CONCLUSION A dose of 0.6 mg/kg succinylcholine can be used for rapid sequence induction of anaesthesia, as it provides acceptable intubating conditions with a shorter apnoea time compared with a dose of 0.8 mg/kg.
Authors and Affiliations
Girish K. N, Rajashekar S
Keywords
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- EP ID EP538432
- DOI 10.14260/jemds/2018/746
- Views 45
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